Growing Up in Singapore Towards Healthy Outcomes

Active, not recruiting

• Conditions: Metabolic Diseases; Socioeconomic Factors; Psychology, Social; Neurological and Mental Health Conditions; Genetic Predisposition; Skin Condition; Environmental Exposure

• Registration Number: NCT01174875
• Lead Sponsor: National University Hospital, Singapore

Brief Summary

This study aims to examine the role of genetic and epigenetic factors, maternal nutrition, lifestyle, emotional health, and other environmental factors in pregnancy or postpartum period that can influence future maternal risk of metabolic and mental wellness, including body weight changes. The study will recruit women in early pregnancy and later follow their children after birth, tracking both the mother and child until the child reaches at least 20 years of age.

Detailed Description

The dramatic emergence of non-communicable diseases (NCDs) in Asia has coincided with the rapid socioeconomic and nutritional transition taking place in the region, with the prevalence of diabetes rising five-fold in Singapore in less than four decades. One unique aspect of the epidemic has been the significant ethnic differences in predisposition to diabetes among Asians and in the ethnic variation between BMI and the risk of developing insulin resistance, a precursor to type 2 diabetes. Apart from genetic factors, dietary, lifestyle and cultural factors might have influenced the developmental programming through effects on the mechanisms associated with developmental plasticity. A center piece of this study is to examine how epigenetic changes at birth both reflects past developmental influences and, in association with other factors, influences future trajectories of development and its relationship to NCDs. Also factors active during childhood - especially the first 1000 days of life - will be focused upon. The longitudinal GUSTO birth cohort study allows us to examine associations among genetic, environmental and lifestyle interactions in the three distinct ethnic groups, Chinese, Malays and Indians, present in the Singaporean population. Participants have been followed up for their pregnancy outcome, fetal growth and offspring development. In continuation of this research, participants will continue to be followed up through their adolescence phase from the age of 10 to 20 years.

Data will be collected through questionnaires and measurements.

* Questionnaires may be related to socioeconomic factors, healthcare expenses, diet, medical history, behaviour, cognition, lifestyle, sleep, health status, social-emotion factors, and home environment.

* Body measurements such as height, weight, blood pressure, body composition analysis involving bioelectrical impedance analysis (BIA), grip strength.

* Dental examination

* Child pubertal assessments

* Skin clinical assessment and digital photography for assessment of acne presence and severity

* Collection of samples such as blood, buccal swabs, saliva, hair, urine, stool, oral specimen such as exfoliated milk teeth, dental plaque and tongue biofilms

Study Timeline

• Study Start: 2009-06
• Study First Submitted: 2010-07-01
• Study First Submitted QC: 2010-08-03
• Study First Posted: 2010-08-04
• Status Verified: 2025-03
• Last Update Submitted: 2025-04-20
• Last Update Posted: 2025-04-24
• Primary Completion: 2029-07
• Study Completion: 2029-07

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 1247

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Roles of fetal, developmental and epigenetic factors in pathways to disease	Perinatal	To evaluate the role of fixed genetic risk variants, modifiable epigenetic markers, circulating metabolites and hormones in blood, and host-microbe interactions which can reflect past developmental influences, and in association with other factors, affect future trajectories of development and its relationship to NCDs.

Secondary Outcome Measures

Name	Time	Method
Effect of factors in pregnancy and early postpartum period on maternal health	During pregnancy and postpartum period	To examine the role of maternal nutrition, lifestyle, emotional health, and other environmental factors in pregnancy or postpartum period that can influence future maternal risk of metabolic disorders, including body weight changes.
Influence of prenatal and early postnatal factors on child health	During pregnancy and infancy period	To examine the role of maternal nutrition, lifestyle, emotional health, and other environmental factors in infancy that can influence the development of phenotypes in childhood which confer risk for later metabolic and mental disorders.
Influence genetic and epigenetics factors in combination with lifestyle on child health	Childhood and Adolescence up to age 20	To examine the role of genetic and epigenetic factors, lifestyle (physical activity and dietary intake), growth trajectories and other environmental factors that can influence the development of phenotypes in childhood which confer risk for later metabolic and mental disorders.

Trial Locations

Locations (1)

National University Hospital; 🇸🇬 Singapore, Singapore