Toxicogenomic and Immunocytotoxic Effects of Propofol and Isoflurane Anesthetics in Patients Undergoing Elective Surgery

Phase 4

Completed

• Conditions: Types of General Anesthesia; DNA Damage; Patients in Good Health
• Interventions: Drug: Comparison of two anesthetic drugs

• Registration Number: NCT00854178
• Lead Sponsor: UPECLIN HC FM Botucatu Unesp

Brief Summary

The purpose of this study is to evaluate if the anesthetics propofol and isoflurane can damage DNA, induce apoptosis, change expression of genes related to apoptosis and DNA repair and change cytokines profile in patients submitted to elective surgery.

Detailed Description

It is expected that the results provide relevant information to understand the possible adverse effects of anesthetics and contribute to the establishment of strategies aimed at reducing the risks to exposed individuals.

Study Timeline

• Study Start: 2008-03
• Study First Submitted: 2009-03-02
• Study First Submitted QC: 2009-03-02
• Study First Posted: 2009-03-03
• Primary Completion: 2009-12
• Study Completion: 2009-12
• Status Verified: 2010-01
• Last Update Submitted: 2010-01-05
• Last Update Posted: 2010-01-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

• patients in good health American Society of Anesthesia status physical I
• elective minor surgery
• general anesthesia

Exclusion Criteria

• smokers
• alcoholics
• previous medication or radiation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
2	Comparison of two anesthetic drugs	-

Primary Outcome Measures

Name	Time	Method
Evaluation of genotoxicity, gene expression, apoptosis and cytokines profile	within 1 day after surgery

Trial Locations

Locations (1)

Botucatu Medical School, UNESP; 🇧🇷 Botucatu, São Paulo, Brazil