Pharmacogenetics of Propofol and Depth of Anesthesia

Completed

• Conditions: Anesthesia; Propofol

• Registration Number: NCT01029379
• Lead Sponsor: University Hospital, Linkoeping

Brief Summary

Propofol, (2,6-diisopropylphenol) is a short-acting anesthetic drug used for induction and maintenance of anesthesia.

The aim of this study is to evaluate plasma concentrations of propofol in relation to depth of anesthesia, measured by continuous EEG and to correlate plasma concentrations with genetic analyses of liver enzymes responsible for drug elimination.

Our hypothesis is that there is an individual requirement of Propofol plasma concentration depending on genetic differences in drug elimination.

200 patients, ASA classification 1, planned for elective surgery of a duration of at least 30 minutes will be included in this study.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2009-12-09
• Study First Submitted QC: 2009-12-09
• Study First Posted: 2009-12-10
• Study Start: 2010-01
• Primary Completion: 2013-02
• Study Completion: 2013-02
• Status Verified: 2013-03
• Last Update Submitted: 2013-03-01
• Last Update Posted: 2013-03-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Healthy caucasian patents,
• (ASAclassification 1) planned for elective surgery,
• with body mass index 20-30,
• free from analgetic drug > 12 hours prior to anesthesia

Exclusion Criteria

• Pregnancy,
• Smoking,
• allergy to propofol or peanuts,
• alcohol abuse,
• non-caucasian

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
EEG pattern in correlation to clinical anesthesia	20120101	EEG pattern in correlation to clinical anesthesia

Trial Locations

Locations (1)

Department of Anesthesia and Intensive Care; 🇸🇪 Kalmar, Sweden