The Effect of Frequency and Duration of Breaks in Sitting Time on Metabolic Cardiovascular Risk Factors

Not Applicable

Completed

• Conditions: Sedentary Lifestyle; Overweight and Obesity; Metabolic Disease

• Registration Number: NCT02951624
• Lead Sponsor: Rigshospitalet, Denmark

Brief Summary

The primary aim of this study is to investigate the acute effect of the frequency and duration of breaks in sitting time on the metabolic risk factor profile.

Detailed Description

Fifteen (n=15) sedentary adult overweight males will be included in the study. All participants will undergo the four interventions in a randomized cross-over design. Wash out between intervention will be minimum four days.

Control (CON): Participants will be sedentary. Sedentary time will be spent sitting in a chair, restricted to sedentary behaviors (working on a computer, reading, watching TV, etc.), with a target MET below 1.5 (i.e. 1.5 times REE). Participants will only be allowed to stand or walk to go to the toilet.

Breaker: Participants will be breaking up prolonged sitting with 2 min intervals of low intensity walking.

Intermediate: Participants will be breaking up prolonged sitting with 6 min intervals of low intensity walking

Prolonger: Participants will be breaking up prolonged sitting with 12 min intervals of low intensity walking

All interventions will be matched for total physical activity as well as sitting. Thus, we aim for the active interventions to be iso-caloric.

Study Timeline

• Study First Submitted: 2016-10-30
• Study First Submitted QC: 2016-10-30
• Study Start: 2016-11
• Study First Posted: 2016-11-01
• Primary Completion: 2018-07-15
• Study Completion: 2018-07-15
• Status Verified: 2018-12
• Last Update Submitted: 2018-12-12
• Last Update Posted: 2018-12-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 14

Inclusion Criteria

• Males, age 20-50 years, waist-to-height ratio ≥ 0.5 and/or waist circumference ≥ 102 cm.

Exclusion Criteria

• Clinically diagnosed diabetes, uncontrolled hypertension, use of glucose- and/or lipid-lowering medication, smoking, evidence of thyroid, liver, lung, heart or kidney disease, non-sedentary occupation, and VO2max levels above the considered average fitness according to age (Shvartz & Reibold 1990), contraindications to increased levels of physical activity.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
AUC post prandial glucose concentration	6 hours

Secondary Outcome Measures

Name	Time	Method
AUC post prandial hdl concentration	6 hours
AUC post prandial insulin concentration	6 hours
AUC post prandial c-peptide concentration	6 hours
AUC post prandial glucagon concentration	6 hours
Variation in 24 hour glucose concentration	24 hours
AUC post prandial triglyceride concentration	6 hours
AUC post prandial ldl concentration	6 hours
AUC post prandial total cholesterol concentration	6 hours
Maximum in 24 hour glucose concentration	24 hours
Mean 24 hour glucose concentration	24 hours

Trial Locations

Locations (1)

Center for Physical Activity Research, Copenhagen University Hospital; 🇩🇰 Copenhagen, Denmark