The Effect of Frequency and Duration of Breaks in Sitting Time on Metabolic Cardiovascular Risk Factors
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- AUC post prandial glucose concentration
研究概览
简要总结
The primary aim of this study is to investigate the acute effect of the frequency and duration of breaks in sitting time on the metabolic risk factor profile.
详细描述
Fifteen (n=15) sedentary adult overweight males will be included in the study. All participants will undergo the four interventions in a randomized cross-over design. Wash out between intervention will be minimum four days.
Control (CON): Participants will be sedentary. Sedentary time will be spent sitting in a chair, restricted to sedentary behaviors (working on a computer, reading, watching TV, etc.), with a target MET below 1.5 (i.e. 1.5 times REE). Participants will only be allowed to stand or walk to go to the toilet.
Breaker: Participants will be breaking up prolonged sitting with 2 min intervals of low intensity walking.
Intermediate: Participants will be breaking up prolonged sitting with 6 min intervals of low intensity walking
Prolonger: Participants will be breaking up prolonged sitting with 12 min intervals of low intensity walking
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Males, age 20-50 years, waist-to-height ratio ≥ 0.5 and/or waist circumference ≥ 102 cm.
排除标准
- •Clinically diagnosed diabetes, uncontrolled hypertension, use of glucose- and/or lipid-lowering medication, smoking, evidence of thyroid, liver, lung, heart or kidney disease, non-sedentary occupation, and VO2max levels above the considered average fitness according to age (Shvartz & Reibold 1990), contraindications to increased levels of physical activity.
研究组 & 干预措施
Control
Participants will spend 8 hours sedentary. Sedentary time will be spent sitting in a chair, restricted to sedentary behaviors (working on a computer, reading, watching TV, etc.) Participants will only be allowed to stand or walk to go to the toilet.
干预措施: Control (Behavioral)
Breaker
Participants will spend a total of 7 hours and 12 min sedentary and a total of 48 min breaking sitting time with LPA. Sedentary time will be done in bouts of 18 min with 2 min of light walking.
干预措施: Breaker (Behavioral)
Intermediate
Total duration of sedentary time and LPA time will be the same as in Breaker. Sedentary time will be done in bouts of 54 min with 6 min of LPA between each bout.
干预措施: Intermediate (Behavioral)
Prolonger
Total duration of sedentary time and LPA time will be the same as in Breaker. Sedentary time will be done in bouts of 108 min with 12 min of LPA between each bout.
干预措施: Prolonger (Behavioral)
结局指标
主要结局
AUC post prandial glucose concentration
时间窗: 6 hours
次要结局
- Variation in 24 hour glucose concentration(24 hours)
- AUC post prandial hdl concentration(6 hours)
- Mean 24 hour glucose concentration(24 hours)
- AUC post prandial insulin concentration(6 hours)
- AUC post prandial c-peptide concentration(6 hours)
- AUC post prandial glucagon concentration(6 hours)
- AUC post prandial triglyceride concentration(6 hours)
- AUC post prandial ldl concentration(6 hours)
- AUC post prandial total cholesterol concentration(6 hours)
- Maximum in 24 hour glucose concentration(24 hours)
研究者
Mathias Ried-Larsen
Group leader
Rigshospitalet, Denmark