Effect of Frequent Interruptions of Prolonged Sitting on Self-perceived Levels of Energy, Mood, Food Cravings and Cognitive Function

Not Applicable

Completed

• Conditions: Food Cravings; Mood; Energy; Cognitive Function

• Registration Number: NCT02717377
• Lead Sponsor: University of Colorado, Denver

Brief Summary

This study is designed to test the effects of six 5 minute microbursts of physical activity spread across the day as compared to either a sedentary control condition or a single 30 minute bout of moderate intensity physical activity on cognitive function, self-reported energy levels, aspects of eating behavior and measures of metabolic health. The primary hypotheses are:

1. Hourly 5 minute bouts of moderate intensity exercise during the day will increase afternoon cognitive function as compared to a no exercise condition.

2. Hourly 5 minute bouts of moderate intensity exercise during the day will increase afternoon cognitive function more than a single 30 minute AM bout.

Secondary exploratory hypotheses include

1. Hourly 5 minute bouts of moderate intensity exercise during the day will increase self-reported energy levels, reduce orexigenic appetitive measures and improve measures of metabolic health as compared to a no exercise condition.

2. Hourly 5 minute bouts of moderate intensity exercise during the day will increase self-reported energy levels, reduce orexigenic appetitive measures and improve measures of metabolic health more than a single 30 minute AM bout.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-11
• Primary Completion: 2014-05
• Study Completion: 2014-05
• Study First Submitted: 2016-02-22
• Status Verified: 2016-03
• Study First Submitted QC: 2016-03-17
• Last Update Submitted: 2016-03-17
• Study First Posted: 2016-03-23
• Last Update Posted: 2016-03-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. All ethnic groups and both genders
2. Age: Lower age limit: 19 years; Upper age limit: 45 years
3. Body-mass Index: Lower BMI limit: 18.5 kg/m2; Upper BMI limit: 29.9 kg/m2
4. Willing to adhere to caffeine restrictions of no more than two 16 ounce beverages in the morning of each study day with no caffeine intake after 12:00pm on any of the three study days

Exclusion Criteria

1. History of cardiovascular disease, including coronary artery disease, congestive heart failure, & unstable angina, or uncontrolled hypertension (>140/90 mm Hg)
2. Currently smoking or stopped smoking in the last 6 months
3. Medications affecting weight, energy intake, or energy expenditure in the last 6 months
4. Use of oral steroids
5. History of stroke or seizures, thyroid disease, type 1 or 2 diabetes, Cushing's syndrome, cerebrovascular, renal disease, hepatic disease, arrhythmias
6. Cancer requiring treatment in the past 5 years, with the exception of skin cancers other than melanoma
7. Infectious diseases: Self-reported HIV positivity or active tuberculosis
8. Inability to exercise for more than 30 minutes on a treadmill at moderate intensity
9. Currently pregnant, lactating or less than 6 months post-partum
10. History of a major psychiatric disorder including schizophrenia, bipolar illness or psychotic depression
11. Score of >25 on Beck Depression Inventory
12. No recreational drug use including marijuana in the past 1 year

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Change in Cognitive function	During each of the three separate study days cognitive function is measured at (in minutes): T410	The flanker task is used to measure cognitive function
Change in Cognitive Function	During each of the three separate study days cognitive function is measured at (in minutes): T425	After the Flanker task, the Comprehensive Trail Making Test is used to measure cognitive function during each study day.
Change in Energy and Mood level	During each of the three separate study days energy and mood levels are assessed at (in minutes): T0, T40, T70, T80, T90, T120, T140, T230, T350, T390, T400, T405, T410, and T435	Self-perceived energy and mood were measured by using visual analogue scales (VAS) as described below at baseline.