Obstructive Sleep Apnoea and Cardiovascular Disease

Phase 3

Recruiting

• Conditions: Obstructive Sleep Apnoea (OSA); Respiratory - Sleep apnoea

• Registration Number: ACTRN12605000271606
• Lead Sponsor: HMRC

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2005-09-02
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: Male
• Target Recruitment: 20

Inclusion Criteria

Severe OSA based on polysomnography (Respiratory Disturbance Index (RDI) 25 ).

Exclusion Criteria

History of other cardiovascular or respiratory disease including hypertension, hypercholesterolemia, ischaemic heart disease or diabetesSmoker Treatment with cardiovascular or respiratory medication.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Measure the effect that short term hypoxia has on the change in augmentation index (AIx, an index of arterial stiffness)[Measured continuously during the 40 minute protocol.]

Secondary Outcome Measures

Name	Time	Method
Changes in heart rate[This will be measured continously during the 40 minute protocol.];Changes in blood pressure[This will be measured continously during the 40 minute protocol.];Changes in peripheral arterial tonometry[This will be measured continously during the 40 minute protocol.];Changes in ventilation with hypoxic exposure[This will be measured continously during the 40 minute protocol.]