Cerebrospinal Fluid Proteom in Dependence of Intranasal Breast Milk

• Conditions: Hydrocephalus in Infants

• Registration Number: NCT04229693
• Lead Sponsor: University Hospital of Cologne

Brief Summary

Investigation of the cerebrospinal fluid proteom in preterm infants with posthemorrhagic hydrocephalus in our neonatology center with analysis for modulation of proteom in dependence of breastmilk feeding and way of application such as via gavage tube, oral or nasal application.

Detailed Description

Since the nasal route might be highly effective for neurotrophins and other growth factors the cerebrospinal fluid will be investigated using mass spectrometry to identify modulating effects of intranasal breast milk application on the cerebrospinal fluid proteom.

Study Timeline

• Study First Submitted: 2020-01-13
• Study First Submitted QC: 2020-01-13
• Study First Posted: 2020-01-18
• Status Verified: 2020-02
• Study Start: 2020-02-07
• Last Update Submitted: 2020-02-07
• Last Update Posted: 2020-02-11
• Primary Completion: 2021-02
• Study Completion: 2021-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• preterm infant with hydrocephalus and regular drainage

Exclusion Criteria

• Inborn error of metabolism

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cerebrospinal fluid proteom	weeks	Cerebrospinal fluid analysis using mass spectrometry including proteomic analysis for differences in dependence of intranasal breast milk application

Trial Locations

Locations (1)

Neonatology at the University Hospital of Cologne; 🇩🇪 Cologne, Germany