Feasibility of Assessing Muscle Displacement and Muscle Excursion on Muscle Fatigue, With and Without Preventive Strategies

Not Applicable

Active, not recruiting

• Conditions: Muscle Fatigue

• Registration Number: NCT07102602
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

Study Subjects: This study will recruit healthy males aged 18 to 35 who regularly exercise for at least 2.5 hours per week.

Expected Number of Participants: 20.

Methods and Procedures: This trial will be randomized into two groups, Groups A and B, who will undergo two isokinetic concentric exercise sessions (fatiguing exercise) separated by 15 days. Group A will first receive a fatigue prevention strategy (high-energy laser) followed by a placebo-controlled no-fatigue strategy 15 days later. Group B will first receive a placebo-controlled no-fatigue strategy followed by a fatigue prevention strategy (high-energy laser) 15 days later. The fatigue prevention strategy involves irradiating the quadriceps femoris with a 900-joule high-intensity laser therapy (3-watt output power for 5 minutes) before the isokinetic concentric exercise. The no-fatigue strategy (sham-controlled) involves irradiating the quadriceps femoris with a 0-joule high-energy laser (0-watt output power for 5 minutes) before the isokinetic concentric exercise. Muscle displacement, muscle excursion, as well as muscle electrophysiological changes, force output, and microcirculation parameters were measured before and after exercise to verify the feasibility of muscle displacement and migration for muscle fatigue assessment, and to further establish their impact and application value in muscle fatigue prevention strategies (high-intensity laser therapy).

Detailed Description

Not available

Study Timeline

• Study Start: 2024-11-30
• Primary Completion: 2025-02-25
• Status Verified: 2025-07
• Study First Submitted: 2025-07-31
• Study First Submitted QC: 2025-07-31
• Last Update Submitted: 2025-07-31
• Study First Posted: 2025-08-04
• Last Update Posted: 2025-08-04
• Study Completion: 2025-11-30

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: Male
• Target Recruitment: 20

Inclusion Criteria

• healthy male aged between 18 and 35 years who engage in regular physical activity for at least 2.5 hours per week

Exclusion Criteria

• history of musculoskeletal injuries or lower limb muscle strains involving the dominant lower limb within the past six months
• history of surgical interventions on the dominant lower limb

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Muscle displacement	pre-fatigue (baseline), immediately post-fatigue, 5, 10, 20 minutes post-fatigue

Trial Locations

Locations (1)

National Taiwan University College of Medicine; 🇨🇳 Taipei, Taipei city, Taiwan