Trauma & Control: Self-Regulation of Brain Networks in PTSD

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 32

Inclusion Criteria

PTSD symptoms, according to DSM-5 criteria, as noted by participant's clinician

Exclusion Criteria

• History of episode of psychotic or manic symptoms.
• Daily intake of benzodiazepines, or otherwise irregular intake of
benzodiazepines (*when needed*) but unable to withhold intake from the day
prior to each test session until the end of the each test session. An exception
is made for low doses of short-acting benzodiazepines that are prescribed for
insomnia (i.e. as sleep medication).
• A relevant neurological disorder (e.g., stroke, epilepsy, Multiple Sclerosis)
or severe physical disorder which is likely to impact assessment procedures or
results.
• Reports to be unable or unwilling to withhold recreational drug use and limit
alcohol use to maximally two units per day from the day prior to each test
session until the end of the each test session.
• Reports to be unable or unwilling to discuss frequency and timing of smoking
during and around study procedures, and adhere to an agreed smoking schedule
(personally adjusted to balance feasibility, participant needs and reliability
of study outcomes).
• General learning disability, or known to have intelligence Quotient (IQ) < 70
• Body weight >250 Kg.
• For women: pregnancy
• Contraindications for MRI scanning (e.g., pacemaker, implanted metal parts,
metal in or around the body, deep brain stimulation, severe claustrophobia).

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome of the study is the behavioural effect of the application<br /><br>of self-regulation strategies learned from neurofeedback training on<br /><br>suppression-induced forgetting in the cognitive task. We expect that PTSD<br /><br>patients can apply learned self-regulation strategies to improve memory<br /><br>suppression.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcome measures include an assessment of self-regulation performance<br /><br>based on fMRI data, as well as effects of the application self-regulation<br /><br>strategies on daily EMA survey outcomes.</p><br>