The Effect of Lisinopril and Verapamil on Circulating Angiopoietin 2 and Endostatin in Hypertensive Diabetic Patients with Nephropathy
Not Applicable
- Conditions
- Kidney Disease
- Registration Number
- PACTR201907856711564
- Lead Sponsor
- faculty of pharmacy ain shams university
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Other
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
T2DM patients aged between 45 and 65 years.
5 years’ disease duration.
Active DN in the form of microalbuminuria (UACR: 30-300 mg/g) in two of three samples over a 3 months’ period prior to study.
Hemoglobin A1C (HbA1c) =8.5%.
Exclusion Criteria
Active urinary tract infection.
End Stage Renal disease.
End Stage Liver disease.
Cancer.
Hematological disorders.
Patients taking immunosuppressive medicine.
a recent history of acute myocardial infarction, stroke, or occlusive.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method urinary albumin creatinine ratio,endostatin and angiopoitien 2 kidney damage biomarkers
- Secondary Outcome Measures
Name Time Method fasting blood glucose, glycated hemoglobin and lipid profile