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Clinical Trials/NCT02583750
NCT02583750CompletedNot Applicable

Snooze Control: The Effect of Sleep Deprivation on Glucose Metabolism

Xuewen Wang1 site in 1 country16 target enrollmentStarted: January 1, 2014Last updated:
Conditions
Interventions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Sponsor
Enrollment
16
Locations
1
Primary Endpoint
Glucose concentrations during oral glucose tolerance test

Study Overview

Brief Summary

This project investigated how glucose metabolism differs due to sleep deprivation for three consecutive nights as compared to sufficient sleep for three nights by examining concentrations of glucose, insulin, and other factors involved in glucose metabolism.

Detailed Description

16 participants were enrolled in the study (8 females, 8 males) aged 18-25 years. In order for the participants to qualify for the study, each had to wear a pedometer for a week before the study began to determine eligibility. Each participant came to the lab for an oral glucose tolerance test on a morning, following three nights when they were sleep deprived, and on another morning when they had three nights' sufficient sleep. The sequence of the oral glucose tolerance tests were randomly assigned. The sleep duration for participants was monitored by the readings of the sleep monitors that each participant wore. The oral glucose tolerance tests were performed after an overnight fast. A 20-gauge polyethylene catheter was placed in the antecubital vein for blood sampling. Blood samples were drawn once (0 min) before and 4 times (30, 60, 90, and 120 min) after a 75g glucose drink was consumed for the determination of plasma glucose, insulin, and concentrations of other factors. Each participant was told to continue their regular routine during the study period, including diet, caffeine usage, and exercise.

Study Design

Study Type
Interventional
Allocation
Non Randomized
Intervention Model
Crossover
Primary Purpose
Health Services Research
Masking
None

Eligibility Criteria

Ages
18 Years to 25 Years (Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • •healthy college-aged males and females
  • •being minimally active

Exclusion Criteria

  • •average more than 15,000 steps a day
  • •major health issues such as heart disease, diabetes
  • •taking medication to help with sleep or using a sleeping device
  • •any type of sleep problem such as sleep apnea

Arms & Interventions

OGTT after deprived sleep first

Experimental

Participants came to the lab to perform the oral glucose tolerance test after three nights of sleep deprivation, then another test after three nights of sufficient sleep

Intervention: OGTT after deprived sleep first (Behavioral)

OGTT after sufficient sleep first

Experimental

Participants came to the lab to perform the oral glucose tolerance test after three nights of sufficient sleep, then another test after three nights of deprived sleep

Intervention: OGTT after sufficient sleep first (Behavioral)

Outcomes

Primary Outcomes

Glucose concentrations during oral glucose tolerance test

Time Frame: two hours

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor
Xuewen Wang
Sponsor Class
Other
Responsible Party
Sponsor Investigator
Principal Investigator

Xuewen Wang

Dr. Xuewen Wang, PhD.

University of South Carolina

Study Sites (1)

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