Association Between Early Change in PaCO2 After ECMO Initiation and Neurological Outcome in Newborns
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 4,072
- 试验地点
- 1
- 主要终点
- Acute Neurological Event
研究概览
简要总结
Investigation of the association between PaCO2 change after extra corporeal membrane oxygenation (ECMO) initiation and neurological outcome and mortality in neonates treated by ECMO for respiratory failure.
详细描述
Retrospective analysis of the ELSO database investigating the association between the change of PCO2 value after ECMO start and the risk of acute neurological event under ECMO defined by the onset of cerebral bleeding and/or ischemic stroke and/or clinical or electrical seizure and/or brain death.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 1 Day 至 28 Days（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Acute Neurological Event
时间窗: Up to 90 days after ECMO initiation
Onset of cerebral bleeding and/or ischemic stroke and/or clinical or electrical seizure and/or brain death. The outcome (ANE) was defined by the occurrence of almost one of the following item: * Ischemic or hemmorrhagic stroke diagnosed by ultrasounds, CT or MRI * Clinical or electrical seizures : diagnosed by ElectroEncepahloGraphy (EEG) * Brain death clinically diagnosed
次要结局
- 28-day mortality(28 days after ECMO start)