Comparison of Reduction Ratio of Indoxyl Sulfate between Combination of High Cut off Membrane Hemodialysis with Hemoperfusion and High Efficiency Online-Hemodiafiltration with High Flux Membrane; an Open-Labelled Randomized Crossover Control Trial
Phase 4
- Conditions
- end stage renal diseaseindoxyl sulfatehemoperfusionhemodiafiltrationhigh cut off membranehemodialysis
- Registration Number
- TCTR20170123001
- Lead Sponsor
- The kidney foundation of Thailand
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Enrolling by invitation
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
1. ESRD on hemodialysis at King Chulalongkorn memorial hospital at least 1 year.
2. Age between 18-80 years.
3. Residual renal function less than 100 ml/day.
4. Vascular access flow more than 400 ml/min.
5. On regular HDF 3 times/week and Kt/V more than 1.2.
6. NO intradialytic hypotension at lease 2 weeks before enrollment.
Exclusion Criteria
1. Active infection, malignancy or cardiovascular disease.
2. Pregnancy
3. Contraindication for anticoagulant.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method reduction ratio of indoxyl sulfate between HCO HD with hemoperfusion and post dilution OL-HDF 20 weeks HPLC technique
- Secondary Outcome Measures
Name Time Method reduction ratio of B2 microglobulin between HCO HD with hemoperfusion and post dilution OL-HDF 20 weeks ELISA