Quality of life and Paracetamol In advanced Dementia
- Conditions
- Advanced dementia, Quality of Life, Paracetamol, long-term care facility<br />Gevorderde dementie, Kwaliteit van leven, Paracetamol, verpleeghuis
- Registration Number
- NL-OMON24190
- Lead Sponsor
- eiden University Medical Center (LUMC)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 95
Inclusion Criteria
Diagnosis of dementia, Reisberg Global Deterioration Scale 5-7 Age 65 years or older QUALIDEM (Quality of life) score below the expected median score of 70) Not using any pain medication one week before start study. Residents with PRN prescribed paracetamol (as needed) are also eligible, if the use of paracetamol in the last week was not more than 1 gram/day and less than 3 grams/week
Exclusion Criteria
Presence of a severe psychiatric disorder, Severe liver insufficiency/disease, Use of >4 units alcohol per day, Allergy to study drugs, Concomitant use of flucloxacillin, carbamazepine, fenytoïne, fenobarbital, isoniazide and/or rifampicine, Weight < 50 kg
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Quality of life: QUALIDEM, DS-DAT
- Secondary Outcome Measures
Name Time Method europsychiatric symptoms of dementia (NPI-NH)<br /><br>ADL functioning (Katz-15)<br /><br>Care dependency (CDS)<br /><br>Pain (MOBID-2)<br /><br>Medication use