The effect of prophylactic preoperative probiotic therapy on perioperative endotoxin levels in cardiac surgery patients.
- Conditions
- Cardiac surgery patients.Cardiovascular - Other surgery
- Registration Number
- ACTRN12605000572662
- Lead Sponsor
- Intensive Care Unit, RMH
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 40
Patients scheduled for elective cardiac surgery requiring cardiopulmonary bypass will be approached for consent to participate in the study.
Current usage of a probiotic product (eg Yakult, which is freely available as a foodstuff), past history of asthma or recurrent urticaria, pregnancy, HIV infection, immunosupression and pre-existing intestinal disorder. The Lactobacillus acidophilus preparation to be used in this study contains a very small amount of MSG (total dose 20 mg/day, equivalent to 10% of the initial dose used to test for MSG sensitivity) and as a precaution, patients with asthma or recurrent urticaria will be excluded. As the Lactobacillus preparation contains live microrganisms, immunosupressed and pregnant patients will also be excluded.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome variable of this study is endotoxin rise in the first 24 hours post-commencement of surgery[]
- Secondary Outcome Measures
Name Time Method Peak IL-6 levels in the first 24 hours post-operatively.[];The development of post-operative generalised inflammation and low systemic vascular resistance in the post-operative period.[]