Epithelial barrier in obesity
Completed
- Conditions
- morbide obesitasObesityoverweight10003018
- Registration Number
- NL-OMON36545
- Lead Sponsor
- Catharina-ziekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
Morbid obese patients candidates for bariatric surgery
Control group consists of age and gender matched lean control subjects.
Exclusion Criteria
- Use of antibiotics or infections in the last 4 weeks
- History of gastrointestinal surgery (excl. cholecystectomy/appendectomy)
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Primary Objectives:<br /><br>• To study whether intestinal permeability differs between morbidly obese<br /><br>patients and lean subjects<br /><br>• To assess the effects of weight loss after sleeve gastrectomy on gut<br /><br>permeability<br /><br><br /><br>.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary Objectives:<br /><br>• To study differences in intestinal microbial composition between morbidly<br /><br>obese and lean subjects<br /><br>• To assess the effects of weight loss after sleeve gastrectomy on gut<br /><br>microbiota.<br /><br>• To assess immune activation and inflammation in obesity in exhaled air, blood<br /><br>and stool samples<br /><br>• To assess whether obesity associated changes in permeability are associated<br /><br>with an altered gut microbiota, and with changes in the inflammatory and immune<br /><br>profile</p><br>