The role of perivascular adipose tissue in the regulation of insulin sensitivity through muscle microvascular recruitment in individuals with obesity or type 2 diabetes before and after bariatric surgery.
- Conditions
- Diabetes100192801001265310047066
- Registration Number
- NL-OMON43075
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 36
Female -Caucasian -age 18-55 years -BMI is *35 kg/m2
Bariatric surgery participants getting an operation at the OLVG, location West. Control participants getting a cholecystectomy at the OLVG west.
Documented CVD -Stage 2 hypertension (resting blood pressure >160/100 mmHg) -Obstructive sleeping apnea syndrome (OSAS). -History of severe inflammatory conditions in the past 15 years -Recent infections -recent history (<12 months) of high alcohol use > 4 U/day, more than 3 days in a row -Use of medication potentially affection insulin sensitivity, microvascular function or inflammation -Use of anticoagulants (types Warfarin and Coumadin derivatives) that can increase the risk of bleeding during the muscle biopsy (exception is made for aspirin). -Malignancies (except those of the skin), renal and hepatic diseases. -Smoking -Recent (<6 months) marked (>10%) changes in body weight.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>From the pre- and post operative time points we will study functional and<br /><br>inflammatory properties of PVAT and correlate them with whole-body and<br /><br>microvascular insulin sensitivity. We will correct for anthropometry and<br /><br>systemic inflammation and circulating adipocytokines (IL-6, IL-8, leptin,<br /><br>TNF-*, MCP-1, adiponectin, resistin and PAI-1, fibrinogen) . </p><br>
- Secondary Outcome Measures
Name Time Method <p>-</p><br>