Genetic Susceptibility to Papilloma-induced Voice Disturbance

Completed

• Conditions: RRP; warty recurrent disease in the larynx; 10083624

• Registration Number: NL-OMON36369
• Lead Sponsor: Center for Genomic Sciences/ Allegheny General Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

Patient must have been diagnosed with Recurrent Respiratory Papillomatosis(RRP) by an
otolaryngologist. Biological mother and father of such patients: If either mother or father of such patients are not available then full siblings will be invited to participate.

Exclusion Criteria

None in the Satellite Design

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Most genes contain multiple single nucleotide polymorphisms (SNP) that allow<br /><br>one to differentiate different alleles by their characteristic SNP pattern.<br /><br>Software will be used to automate the process of identifying the genotype of<br /><br>each affected individual and to compare it to that of his/her parents and to<br /><br>that of unrelated controls.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>-</p><br>