Dexmedetomidine Infusion and Postoperative Lung Aeration After Thoracic Surgery

Not Applicable

Recruiting

• Conditions: Surgery-Complications; Respiratory Complication; Lung Injury, Acute

• Registration Number: NCT06502002
• Lead Sponsor: Brigham and Women's Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-8-31
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Inclusion Criteria:<br><br>• Adult patients (Age >18 years until 80 years) undergoing lobectomy and/or<br>segmentectomy.<br><br>Exclusion Criteria:<br><br> - Urgent or emergency thoracic surgery.<br><br> - Other concomitant non-pulmonary procedures (pleurectomy, diaphragmatic procedures,<br> pericardiocentesis, esophageal procedures, thymectomy).<br><br> - Prior lung resection surgery.<br><br> - Epidural block for intraoperative or postoperative analgesia.<br><br> - Preoperative arrhythmia (second degree AV block or pacemaker) or significant<br> bradycardia (heart rate < 50).<br><br> - Preoperative hypotension (mean arterial blood pressure < 65 mmHg).<br><br> - Severe functional liver or kidney disease.<br><br> - Non-English speakers<br><br> - Consent withdrawal.

Exclusion Criteria

Not provided

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Lung aeration

Secondary Outcome Measures

Name	Time	Method
Diaphragmatic dysfunction: defined as a diaphragmatic excursion < 1cm;Intraoperative hypoxemia (SpO2 < 90%);Postoperative atelectasis;Pneumonia;Acute Respiratory Distress Syndrome (ARDS);Pulmonary edema;Reintubation