Effect of drug given during spine surgery for old aged patients on Recovery and mentatio
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2020/06/026077
- Lead Sponsor
- Indraprastha Apollo Hospital New Delhi
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Patients with American Society of Anesthesiologists (ASA) physical status I-III aged 60- 80 years old, undergoing elective lumbar spine surgery
1.Patients age less than 60 years and more than 80 years old.
2.Patients with a pre-operative or intraoperative ECG (electrocardiogram) that showed severe bradycardia (sinus rhythm, heart rate less than 50/ min) or conduction block
3.Patients with associated renal, hepatic and respiratory dysfunction.
4.Patients with history of central nervous system disease such as head injury, stroke, previous neurosurgery, behavioral disturbances or mental retardation.
5.Patients with preoperative cognitive dysfunction (MMSE <24)
6.Patients on β-blockers, cimetidine, digoxin, α2-agonists, anticonvulsants or psychotropic medications
7.Patients with allergy to dexmedetomidine or another alpha-2 adrenergic receptor agonist
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.Mini- Mental State Examination (MMSE) Scores. <br/ ><br>2.15-item quality of recovery score (QoR15) questionnaire. <br/ ><br> <br/ ><br>Timepoint: 1. Before Anaesthesia <br/ ><br>2. Day 1 of Surgery <br/ ><br>3. Day 2 of Surgery <br/ ><br>4. Day 3 of Surgery <br/ ><br> <br/ ><br>
- Secondary Outcome Measures
Name Time Method 1.Intraoperative propofol consumption. <br/ ><br>2.Intraoperative and postoperative fentanyl requirement. <br/ ><br>3.Haemodynamic changes <br/ ><br>Timepoint: till the duration of surgery