Intraoperative effects of dexmedetomidine infusion in adult living donors undergoing hepatic resections for liver transplantation: A randomized control trial.
Phase 4
- Conditions
- Anaesthesia
- Registration Number
- PACTR201909557694667
- Lead Sponsor
- national liver institute menoufeya university
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
All donors fulfilled the eligibility criteria for donation including a within normal liver histology and a volumetric study of the whole liver and the right lobe.Age 18-45 years old, ASA I, normal liver functions, coagulation profiles and normal renal functions.
Exclusion Criteria
inability to give written consent, hemoglobin level < 10 g/dl. Any contraindication for donation.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method we primary investigated the ability of intraoperative infusion of dex in adult living donors undergoing hepatic resections for liver transplantation in the protection of the hepatic parenchyma assessed by laboratory data , including ALT, AST, bilirubin, INR, and lactate (reflecting the degree of hepatocellular injury, elimination and synthetic dysfunctions) and serum ICAM-1 level measurement (reflecting the magnitude of the endothelial cell damages and the severity of inflammatory reactions .
- Secondary Outcome Measures
Name Time Method secondary we evaluated the effects of Dex infusion on the general anaesthetic requirements.