Mitochondrial Metabolism and Hepatic Complications of Obesity
Not Applicable
Withdrawn
- Conditions
- Obesity
- Interventions
- Other: liver biopsy
- Registration Number
- NCT03302481
- Lead Sponsor
- Nantes University Hospital
- Brief Summary
The study aims to characterize mitochondrial metabolism in the liver of obesity surgery patients and to study its relationships with hepatic steatosis, inflammation, and fibrosis.
- Detailed Description
The study aims to characterize mitochondrial metabolism in the liver of obesity surgery patients and to study its relationships with hepatic steatosis, inflammation, and fibrosis. The protocols involves a per-operative hepatic needle biopsy for mitochondria characterization and histological scoring of steatosis, inflammation, and fibrosis
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- adult men and women
- affiliated to a social security
- candidate for laparoscopic obesity surgery
Read More
Exclusion Criteria
- Excessive alcohol consumption:> 20 g / day (woman),> 30 g / day (male)
- Chronic viral hepatitis B or C
- Genetic hemochromatosis
- Taking the following drugs for at least 3 months up to 6 months before the scheduled date of obesity surgery: systemic corticosteroids, amiodarone, methotrexate
- Wilson's disease
- autoimmune hepatitis
- alpha 1-antitrypsin deficiency
- abetalipoproteinemia
- Contraindications to liver biopsy
Read More
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Experimental Group liver biopsy the biopsies will be performed under laparoscopy and taken in the lower part of the right hepatic lobe
- Primary Outcome Measures
Name Time Method Association between nonalcoholic steato-hepatitis and mitochondria morphological markers Until 6 month
- Secondary Outcome Measures
Name Time Method