Comparing the effectiveness of topical voriconazole versus injection of voriconazole and atamycin for recalcitrant fungal keratitis

Completed

• Conditions: Fungal corneal ulcer, fungal keratitis; Ear, Nose and Throat; Keratitis

• Registration Number: ISRCTN57259399
• Lead Sponsor: Dr Rajendra Prasad Centre for Ophthalmic Sciences (India)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-01-10
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1. Patients with a smear or culture proven fungal ulcers
2. Ulcers greater than 2mm in size, involving more than one-third of the stromal thickness and not showing any signs of clinical improvement after two weeks of natamycin
3. Patients who were willing to be treated as an inpatient, willing to follow up regularly, and return for medications regularly every 48-72 hours

Exclusion Criteria

1. Patients with mixed infection on smear or culture, evidence of herpetic keratitis on history or examination, impending perforation, bilateral ulcers, those with vision less than 6/60 in the other eye, pre-existing scar not distinguishable from the new ulcer
2. Those less than 18 years of age

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Best Spectacle Corrected Visual Acuity (BSCVA) 3 months after intervention.

Secondary Outcome Measures

Name	Time	Method
Time to healing