Zooming in at microvascular function in the Rotterdam Study with 7T MRI

Recruiting

• Conditions: neurodegeneratieve aandoeningen; Dementia; vascular pathology; 10042258

• Registration Number: NL-OMON48445
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 200

Inclusion Criteria

- Participant in Rotterdam Study who has undergone at least one previous
assessment in the study centre (including brain MRI and cognitive testing) and
who will visit the study centre from June 2019 onwards for re-examination
- >60 years of age
- Written informed consent

Exclusion Criteria

- Inclusion criteria are not met
- Unwillingness or inability to give written informed consent
- Clinical diagnosis of dementia or previous stroke.
- Contraindications for 7T MRI (pacemaker, aneurysm clip, cochlear implant etc.)
- Major neurological conditions affecting brain structure (e.g. multiple
sclerosis, epilepsy, parkinson*s disease)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Measures of microvascular function as assessed on noninvasive 7T MRI:<br /><br>- Mean velocity and pulsatility index of perforator flow, both in the basal<br /><br>ganglia and in the semioval center;<br /><br>- Cerebrovascular reactivity (CVR) to a hypercapnic stimulus.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable. </p><br>