NCT01851876已完成不适用
Endometrial Injury May Increase the Clinical Pregnancy Rate in Normoresponders Underwent Long Agonist Protocol Intracytoplasmic Sperm Injection Cycles With Single Embryo Transfer
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 118
- 主要终点
- Clinical Pregnancy Rate
研究概览
简要总结
Endometrial injury increases clinical pregnancy rate in normoresponder patients undergoing long agonist protocol intracytoplasmic sperm injection cycles with single embryo transfer.
详细描述
Endometrial injury means endometrial biopsy on day 3 of menstrual cycle following down regulation in an IVF patient.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •woman age under 35 years
- •history of primary infertility
- •normoresponder (antral follicle count 5-10 in one ovary in early follicular phase
- •having grade I or II embryos for transfer
- •agree to undergo endometrial biopsy during the COH cycle. All patients were stimulated with luteal phase long protocol.
排除标准
- •endocrinopathies (including diabetes mellitus, hyperprolactinemia, Cushing's disease, and congenital adrenal hyperplasia), any systemic disease, collagen disorder, hypercholesterolemia, sickle cell anemia, and a history of neoplasm; -high risk for or history of OHSS
- •using any concurrent medication (e.g., insulin-sensitizing drugs, and GnRH antagonists)
- •patients who did not proceed to follicle retrieval
- •severe male infertility requiring TESA/TESA
- •mullerian tract anomalies
- •a history of endometrial instrumentation or surgery within a month of the study
- •not agree to undergo endometrial biopsy during the COH cycle.
研究组 & 干预措施
Endometrial injury
Experimental
The patients in this group will be subjected to endometrial injury procedure in preceding IVF cycle.
干预措施: Endometrial injury (Device)
No endometrial injury
No Intervention
The patients in this group will not be subjected to endometrial injury procedure in presiding IVF cycle. The patients will be stimulated with standard IVF protocol.
结局指标
主要结局
Clinical Pregnancy Rate
时间窗: 4 months
Clinical Pregnancy Rate
时间窗: up to 6 months
次要结局
未报告次要终点
研究者
Suleyman Guven
Assoc. Prof.
Karadeniz Technical University
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