Alteration of nerve activity in schizophrenia patients with deficits in empathy by additional iTBS over treatment as seen on changes in EEG activity in response to observed biological motio
- Conditions
- Health Condition 1: F20- Schizophrenia
- Registration Number
- CTRI/2023/07/054966
- Lead Sponsor
- Central Institute of Psychiatry
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1. Diagnosis of Schizophrenia using Diagnostic Criteria for Research (DCR) of
International Classification of Disease-10th edition (ICD-10, World Health
Organization,1993).
2. Age between 18-60 years of either sex.
3. Right-handed.
4. On stable dose of any antipsychotic medication (Chlorpromazine equivalent dosage
at least 600mg per day for past 2 weeks)
5. Patients giving written consent.
6. Calgary Depression Scale for Schizophrenia (CDSS) score less than 7.
7. The Positive and Negative Syndrome Scale for Schizophrenia (PANSS) has,
negative symptoms score of more than 15 and a positive score of less than 11.
8. Patients with deficits in empathy defined as scores on Interpersonal Reactivity
Index (more than the respective means) for the 4 domains, namely Fantasy, Perspective Taking, Empathic Concern, Personal Distress
1. Presence of co-morbid neurological or other psychiatric disorder(s).
2. Patient with co-morbid substance dependence, except nicotine and caffeine.
3. Subjects who have received ECT in the past 6 months.
4. Not willing to give informed consent.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reduction in scores of symptoms of schizophrenia as rated by <br/ ><br>Positive & Negative Syndrome Scale (PANSS) and <br/ ><br>increase in scores of Interpersonal Reactivity Index (IRI) <br/ ><br>Timepoint: After completion of iTBS sessions i.e. 10 days after initiation of treatment & 4 weeks thereafter.
- Secondary Outcome Measures
Name Time Method Changes in EEG mu wave suppression in response to observed biological motion in schizophrenia patients with deficits in empathyTimepoint: At completion of iTBS sessions i.e. 10 days after initiation of treatment