Effect of Mechanical Loading With PTH on Cortical Bone
Phase 4
- Conditions
- Osteoporosis, Postmenopausal
- Interventions
- Device: Upper extremity voluntary loading
- Registration Number
- NCT03232476
- Lead Sponsor
- Massachusetts General Hospital
- Brief Summary
Clinical trial to investigate effect of voluntary upper extremity loading in combination with anabolic osteoporosis therapy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 18
Inclusion Criteria
- women aged 45+
- postmenopausal
- osteoporotic with high risk of fracture
Exclusion Criteria
- no significant previous use of bone health modifying treatments
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Loaded upper extremity Upper extremity voluntary loading This is a one-arm study. In postmenopausal women prescribed teriparatide for osteoporosis treatment, enrolled subjects will perform voluntary loading exercises on one upper extremity. A data logger device will assist in recording exercises and determining goal force during the exercises. Each subject's non-loaded upper extremity will serve as a control.
- Primary Outcome Measures
Name Time Method radius bone mineral density 12 month change
- Secondary Outcome Measures
Name Time Method