Pulmonary Impacts of Anaesthetic Modalities Evaluated by Ultrasound

• Conditions: Anesthesia
• Interventions: Diagnostic Test: pleuropulmonary ultrasound

• Registration Number: NCT03978169
• Lead Sponsor: University Hospital, Toulouse

Brief Summary

A prospective, observational, monocentric study aimed at identifying ultrasound changes in anaesthesia on the pulmonary parenchyma after knee arthroplastic surgery using the LUS score in the preoperative, immediate post-operative (D0) and late post-operative (D1) periods.

Detailed Description

Post-operative pulmonary complications are responsible from morbidity and mortality close to cardiovascular complications.

Perioperative and post-operative respiratory changes are secondary to anaesthesia (general anaesthesia, elongated position, tidal volume) and to surgery in particular abdominal and cardiothoracic surgery.

Several risk factors related to patients were identified: age, ASA score\> 2, functional dependence, chronic obstructive pulmonary disease, congestive heart failure, obesity, smoking.

Pulmonary ultrasound is a simple and rapid means of monitoring, widely used in resuscitation and developing in anaesthesia.

The hypothesis of the study is that anaesthesia and / or ventilation is responsible for lung lesions observable by ultrasound from the recovery room, even after extra-thoracic surgeries.

To do this, it will perform 3 pleuro-pulmonary ultrasound scans, preoperatively on the day of surgery, post-operatively in the recovery room and the day after surgery. LUS score will be calculated. Preoperative data (morphology, comorbidities), preoperative (ventilation, filling, position, type of anaesthesia - general anaesthesia with intubation or laryngeal mask, spinal anaesthesia- , type of surgery) and postoperative data (constants, oxygen therapy, complications) will be collected.

Study Timeline

• Study Start: 2018-12-13
• Study First Submitted: 2019-05-28
• Status Verified: 2019-06
• Study First Submitted QC: 2019-06-05
• Last Update Submitted: 2019-06-05
• Study First Posted: 2019-06-07
• Last Update Posted: 2019-06-07
• Primary Completion: 2020-11
• Study Completion: 2020-11

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 99

Inclusion Criteria

• Patient undergoing scheduled primary knee arthroplasty :

• Partial knee replacement surgery

• Total knee replacement surgery

  • Type of Anaesthesia

• General anaesthesia with orotracheal intubation

• General anaesthesia with laryngeal mask

• Spinal anaesthesia

  • Major Patient
  • Oral non opposition collected after oral information of the study

Exclusion Criteria

• Refusal to participate
• Preoperative pleural pathology (pleural effusion, pleural symphysis)
• Pregnancy
• Patient under authorship or curators
• non-affiliation to a social security scheme

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
General anaesthesia with laryngeal mask	pleuropulmonary ultrasound	surgery patient under general anaesthesia with laryngeal mask
General anaesthesia with orotracheal intubation	pleuropulmonary ultrasound	surgery patients under general anaesthesia with orotracheal intubation
Spinal anaesthesia	pleuropulmonary ultrasound	surgery's patients under Spinal anaesthesia

Primary Outcome Measures

Name	Time	Method
lung lesions by the anaesthetic and operative management after knee replacement surgery	24hours post surgery	Describe lung lesions by the anaesthetic and operative management after knee replacement surgery

Trial Locations

Locations (1)

UHToulouse; 🇫🇷 Toulouse, France