Th2 Cytokine Responses in Overweight/Obese Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 46
- 试验地点
- 1
- 主要终点
- Th2 Cytokine levels
研究概览
简要总结
Cytokines are chemicals that are naturally made by your body. Certain cytokine levels are changed in the blood of patients who develop allergies and/or asthma. Cytokine levels may also be changed in some individuals who are overweight or obese. The purpose of this study is to determine if certain cytokine levels differ based on a person's weight and whether or not they have allergies or asthma. Information gathered in this study will be compared to information gathered from subjects who have participated in another similar study for patients who have allergies and/or asthma.
详细描述
The aims of this study are to:
- Characterize the relationship between BMI and Th2 skewing in non-atopic adult subjects.
- Compare these results to those previously obtained from atopic adult subjects It is expected that the results of this study will demonstrate enhanced Th2 skewing in overweight and obese atopic subjects as compared to non-atopic subjects. It is further anticipated that the results of this study will be used as preliminary data to generate an NIH grant application exploring the link between obesity and atopy.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •adults aged 18 to 50 years
- •pre-bronchodilator FEV1 > 80% predicted with no evidence of reversibility following administration of bronchodilator
- •no history of allergies
排除标准
- •medical history consistent with atopy and/or asthma
- •any positive response to allergy skin testing for inhalant allergens (defined as a wheal > 3 mm larger than the negative control)
- •a pre-bronchodilator FEV1 < 80% predicted
- •> 12% reversibility in FEV1 following administration of a bronchodilator
- •any history of significant chronic illness
- •history of respiratory infection within the past 2 weeks
- •any use of prescription medications other than oral contraceptives or thyroid hormone replacement within the past 2 months
- •use of any investigational medication within the past month
结局指标
主要结局
Th2 Cytokine levels
时间窗: Baseline (only visit)
次要结局
未报告次要终点
研究者
David Skoner, MD
Director, Allergy and Asthma Institute
West Penn Allegheny Health System