Whole Brain Vessel Wall Imaging in Stroke Patients (WISP): An International Multi-Center Registry

• Conditions: Ischemic Stroke

• Registration Number: NCT02923752
• Lead Sponsor: Cedars-Sinai Medical Center

Brief Summary

This is a new vessel wall imaging-based stroke registry which will investigate the clinical utility of the whole-brain intracranial vessel wall Magnetic Resonance Imaging (MRI) technique in assessing the etiologies in patients with ischemic stroke.

Detailed Description

The registry will focus on investigating the utility of whole-brain vessel wall MRI techniques in assessing the etiologies in patients with recent ischemic stroke. Patients who have had ischemic stroke (as confirmed by diffusion weighted MRI) and have had or will undergo 3D whole-brain vessel wall MRI within 8 weeks of symptom onset will be recruited into this study. It is anticipated that a total of 1000 subjects will be recruited from Feb 2017 to Feb 2019. Approximately 12 centers in the US and China will participate in the registry. MRI whole-brain vessel wall images will be analyzed for detection and characteristics of various vessel wall pathologies and association between vessel wall imaging findings and patient's clinical information.

Study Timeline

• Study First Submitted: 2016-10-03
• Study First Submitted QC: 2016-10-03
• Study First Posted: 2016-10-05
• Study Start: 2017-02-01
• Status Verified: 2018-08
• Last Update Submitted: 2018-08-13
• Last Update Posted: 2018-08-14
• Primary Completion: 2019-08-01
• Study Completion: 2019-08-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

• Male or female ≥ 18 years of age
• Ischemic stroke onset within 8 weeks and confirmed by diffusion weighted MRI
• Ability to read and understand informed consent

Exclusion Criteria

• The cause of stroke has been confirmed to be related to cardiac or extracranial carotid or aorta pathologies.
• Contraindications to MR imaging including mechanically, magnetically, or electrically activated implants, ferromagnetic implants and ferromagnetic foreign bodies, pregnancy.
• Inability to tolerate MRI imaging secondary to an inability to lie supine or severe claustrophobia.
• Non-compliant with visit instructions, including inability to lie still, hold breath or follow procedure instructions

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Vessel wall pathology findings by MRI	baseline	To identify vessel wall pathologies such as atherosclerosis, dissection, vasculitis

Trial Locations

Locations (12)

Keck Hospital of the University of Southern California; 🇺🇸 Los Angeles, California, United States

Torrance Memorial Medical Center; 🇺🇸 Torrance, California, United States

LiangXiang Hospital; 🇨🇳 Beijiang, China

Xuanwu Hospital, Capital Medical University; 🇨🇳 Beijing, China

Chaoyang Hospital, Capital Medical University; 🇨🇳 Beijing, China

Tianjin First Center Hospital; 🇨🇳 Tianjin, China

Beijing AeroSpace Center Hospital; 🇨🇳 Beijing, China

The First Affiliated Hospital of Zhengzhou University; 🇨🇳 ZhengZhou, China

Fujian Medical University Union Hospital; 🇨🇳 Fuzhou, China

Cedars-Sinai Medical Center; 🇺🇸 Los Angeles, California, United States

Tianjin Huanhu Hospital; 🇨🇳 Tianjin, China

West China Hospital, Sichuan University; 🇨🇳 Chengdu, China