Glucose transport and mitochondrial function in type 1 diabetes mellitus
- Conditions
- diabetes10018424
- Registration Number
- NL-OMON52326
- Lead Sponsor
- Vrije Universiteit
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 41
In order to be eligible to participate in this study, participants with T1DM
must meet all of the following criteria:
• Individuals with T1DM with a diagnosed disease duration of 1 - 45 years
• Male or female
• Aged between 18-65 years
In order to be eligible to participate in this study, healthy control
participants must meet all of the following criteria:
• No chronic health conditions and between the ages of 18-65
• History of asthma, stroke, chronic obstructive pulmonary disease, congestive
heart failure, heart surgery, or congenital heart diseases
• Current treatment with drugs known to interfere with metabolism e.g. systemic
corticosteroids, statins, SGLT2 inhibitors, GLP1 receptor agonists
• Are current smokers or have been a regular smoker within the last 12 months
• Insulin pump therapy
• Symptomatic autonomic or distal neuropathy
• BMI >30 due to adiposity, since this is known to cause difficulties in
obtaining muscle biopsies.
• Pregnancy
• Recent acute myocardial infarction (<6 months)
• Uncontrolled arrhythmia/severe conduction disorder (atrial fibrillation or
second/third degree AV block) causing hemodynamic compromise
• Implantable pacemaker or other cardiac device with complete ventricular pacing
• Uncontrolled heart failure with hemodynamic compromise
• Uncontrolled hypertension (Systolic Blood Pressure >150 mmHg and Diastolic
Blood Pressure > 100 mmHg on repeated measurements)
• Active infection, anaemia, severe renal dysfunction (estimated Glomerular
filtration rate <30 ml/min/1,73m2) likely to significantly impact on exercise
performance
• Chronic illness (including orthopaedic, endocrinological, haematological,
malignant, gastrointestinal, neurological, muscle or inflammatory disorders)
likely to significantly impact on exercise performance
• > 6 alcohol units per day or >14 alcohol units per week
• Use of anticoagulants or anti platelet therapy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Main study parameters: The differences in markers of insulin-independent<br /><br>glucose uptake, parameters of mitochondrial function and exercise tolerance<br /><br>between T1DM and control groups both before and after the exercise training<br /><br>intervention.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary Study Parameters: The differences in exercise tolerance and aerobic<br /><br>function parameters between T1DM and control groups before and after the<br /><br>exercise training intervention, and their relationships with markers of<br /><br>mitochondrial function.</p><br>