iver glycogen dynamics and substrate oxidation in lean healthy volunteers (Follow-up study on study entitled The effect of modulating hepatic glycogen content on hepatic fat oxidation)

Completed

Conditions: Hepatic glycogen
Storage of sugar in the liver
10019654
10018424

Registration Number: NL-OMON49713

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 22

Inclusion Criteria

- Participants are able to provide signed and dated written informed consent
prior to any study specific procedures
- Caucasian (people will be excluded when having a *50% racial African/Asian
background)
- Participants should have suitable veins for cannulation or repeated
venipuncture
- Women are post-menopausal (defined as at least 1 year post cessation of
menses)
- Men and women aged * 45 and * 75 years at the start of the study
- Body mass index (BMI) 18.5 * 25 kg/m2
- Stable dietary habits (no weight loss or gain >3kg in the past 3 months)
- Sedentary lifestyle (not more than 3 hours of vigorous sports per week)
- Liver fat content <5%

Exclusion Criteria

- Type 2 Diabetes Mellitus
- Active diseases (cardiovascular, diabetes, liver, kidney, cancer or other)
- Any contraindication for MRI scanning
- Alcohol consumption of >2 servings per day
- Regular smoking
- No use of medication interfering with investigated study parameters (as
determined by responsible physician)
- Participants who do not want to be informed about unexpected medical
findings, or do not wish that their physician

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study outcome is the change in hepatic glycogen in response to a<br /><br>9.5hrs and a 16 hrs fast, measured with 13C-magnetic resonance spectroscopy<br /><br>(MRS). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Whole body fat oxidation measured using the respiratory quotient (VCO2/VO2)<br /><br>during the night. Oxygen utilization and carbondioxide production are measured<br /><br>using the respiration chamber. </p><br>