Heterogeneity of Activation Recovery Interval and Restitution in Non-Ischemic Cardiomyopathy and its relation to Ventricular Arrhythmias

• Conditions: Life-threatening arrhythmias; Ventricular Arrhythmias; 10007521

• Registration Number: NL-OMON41046
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 45

Inclusion Criteria

Cases: This population will consist of consecutive NICM patients with previous
documentation of ventricular arrhythmias (sustained monomorphic VT, polymorphic VT or
ventricular fibrillation) scheduled for epicardial or endocardial electrophysiological study
with or without ventricular tachycardia ablation.
Controls: This group will consist of consecutive patients without structural heart disease
referred for mapping and ablation of idiopathic Premature Ventricular Contractions.

Exclusion Criteria

All subjects:
Age < 18 years
Inadequate patient competence
Pregnancy
Inability to comply with the protocol due to haemodynamic instability
Non-NICM
Control specific:
Previous history of ventricular arrhythmias
Known pro-arrhythmic genetic mutation or disease

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Electroanatomical mapping data: ARI and APDR values (derived from unipolar<br /><br>signals) from predefined sites<br /><br>Inducibility and type of VA during electrophysiology study<br /><br>Inducibility and type of VA during ARI/APDR pacing protocol<br /><br>Occurrence and type of spontaneous VA during 24 month follow-up</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Mortality (all cause, cardiac, arrhythmic)</p><br>