Blood Flow Restriction Resistance Training Intervention on Vascular Function
- Conditions
- Endothelial Function
- Interventions
- Behavioral: Blood flow restriction resistance training
- Registration Number
- NCT05451641
- Lead Sponsor
- University of Texas at Austin
- Brief Summary
The purpose of this study is to investigate the effect of blood flow restriction (BFR) resistance training on vascular function. The investigators aim to compare the effects of different BFR devices (wide-rigid cuffs and narrow elastic bands) on vascular function. The investigators hypothesize that BFR resistance training with wide-rigid cuffs might have a minor negative effect (short-term and reversible) on vascular function, while BFR resistance training with narrow-elastic bands may improve vascular function. Both training methods are equally effective in increasing muscle strength.
- Detailed Description
Blood flow restriction (BFR) resistance training has been proven to be effective in increasing muscle mass and strength. During BFR training, cuffs (similar to blood pressure cuffs) are placed on the proximal ends of the extremities to partially occlude arterial blood flow to the working muscles and fully restrict venous outflow from the working muscle. The metabolites produced by the working muscle during exercise are trapped in the working muscle, which causes metabolic stress to augment muscle adaptation. Typically, two types of cuffs are used in the BFR training: the narrow-elastic bands and wide-rigid nylon cuffs adapted from surgical tourniquets and blood pressure cuffs.
Currently, the effect of BFR training on vascular function remains unclear. When the cuffs are removed after BFR training, there will be a reactive hyperemic blood flow to wash out all the metabolites produced during exercise. This reactive hyperemic blood flow also will impose shear stress on the arterial vessel wall. The shear stress will lead to an increase in vasodilator factors, which lead to an improvement in vascular function. However, other studies have pointed out that BFR training might cause a negative effect on vascular function when the occlusion pressure was too high. The possible mechanisms of the negative effect might be ischemia-reperfusion injury and retrograde shear stress in the artery. The wide-rigid cuffs are easily available but have the potential to inhibit the expansion of muscle upon increased blood flow accompanying exercise and muscle contraction while the narrow-elastic bands do not prevent the expansion. To the investigators' best knowledge, there is no study directly comparing different BFR cuffs on vascular function. Thus, the aim of the present study is to compare the effects of different BFR cuffs on vascular function (evaluated by flow-mediated dilation, a non-invasive measure of endothelial-derived vasodilation).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 26
- Apparently healthy, sedentary or recreationally active young adults aged between 18 - 40 years old and signed the informed consent.
- A current COVID-19 diagnosis
- morbid obesity
- hypertension
- smoking
- overt cardiovascular disease
- using any medication that might affect the cardiovascular system
- current participation in resistance training.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Wide-rigid cuff Blood flow restriction resistance training The wide-rigid cuff will be randomly assigned to one of the subject's arms. Narrow-elastic band Blood flow restriction resistance training The narrow-elastic band will be randomly assigned to another arm of the subject.
- Primary Outcome Measures
Name Time Method Change from baseline vascular function at 2 weeks Baseline measurement and measurement at 2 weeks Flow-mediated dilation evaluated by an ultrasound machine
Change from baseline muscle strength at 2 weeks Baseline measurement and measurement at 2 weeks Measured by a cable machine in the gym
Change from baseline grip strength at 2 weeks Baseline measurement and measurement at 2 weeks Measured by a hand dynamometer
- Secondary Outcome Measures
Name Time Method Blood flow responses to different types of cuff At 2 weeks Measured by an ultrasound machine
Change from baseline body fat percentage at 2 weeks Baseline measurement and measurement at 2 weeks Measured by a bioelectrical impedance analysis machine
Change from baseline blood lactate concentration At 10 minutes before the training sessions (baseline measurement) and at 10 minutes after the training sessions Measured by a lactometer
Change from baseline fat mass at 2 weeks Baseline measurement and measurement at 2 weeks Measured by a bioelectrical impedance analysis machine
Change from baseline lean body mass at 2 weeks Baseline measurement and measurement at 2 weeks Measured by a bioelectrical impedance analysis machine
Changes from baseline heart rate at the end of each exercise during all the training sessions At 10 minutes before the training sessions (baseline measurement), at 10 minutes, 20 minutes, and 30 minutes during the training sessions Measured by a heart rate monitor
Change from baseline blood pressure at the end of each exercise during all the training sessions At 10 minutes before the training sessions (baseline measurement), at 10 minutes, 20 minutes, and 30 minutes during the training sessions Measured by an Omron digital blood pressure monitor
Change from baseline arterial stiffness at 2 weeks Baseline measurement and measurement at 2 weeks Evaluated by the Omron VP-1000plus device (Non-invasive measurement)
Change of the perceived exertion At 10 minutes, 20 minutes, and 30 minutes during the training sessions Borg rating of perceived exertion scale
Trial Locations
- Locations (1)
Cardiovascular Aging Research Laboratory
🇺🇸Austin, Texas, United States