Effects of BFR Interventions in Healthy Individuals and Individuals With COPD

Not Applicable

Recruiting

• Conditions: Healthy; COPD
• Interventions: Other: BFR during training; Other: BFR during rest

• Registration Number: NCT05734534
• Lead Sponsor: Morten Hostrup, PhD

Brief Summary

The purpose of the study is to investigate the effect of different blood flow restriction (BFR) interventions on muscle function and adaptations both in healthy well-trained individuals and individuals diagnosed with COPD.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-12-23
• Status Verified: 2023-02
• Study First Submitted QC: 2023-02-15
• Last Update Submitted: 2023-02-15
• Study First Posted: 2023-02-21
• Last Update Posted: 2023-02-21
• Study Start: 2023-03-01
• Primary Completion: 2024-04-01
• Study Completion: 2024-08-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 105

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
BFR-ST and BFR-HIT	BFR during training	Participants will be allocated to a BFR intervention including resistance training and high-intensity intervals performed on a bicycle ergometer, both performed with BFR.
Control group	BFR during rest	Participants with COPD experiencing an acute exacerbation of their COPD requiring hospitalization will allocated to usual care, consisting of daily physiotherapy sessions.
HL-ST and HIT	BFR during training	Participants will be allocated to heavy load resistance training and high-intensity intervals performed on a bicycle ergometer, both performed without BFR
BFR-P	BFR during rest	Participants with COPD experiencing an acute exacerbation of their COPD requiring hospitalization will be allocated to application of BFR twice daily throughout their hospitalization. Participants are resting in a supine position throughout the application of BFR.
BFR-NMES	BFR during rest	Participants with COPD experiencing an acute exacerbation of their COPD requiring hospitalization will be allocated to application of BFR with neuromuscular electrical stimulation (BFR-NMES) twice daily throughout their hospitalization. Participants are resting in a supine position throughout the application of BFR-NMES.

Primary Outcome Measures

Name	Time	Method
Muscle strength	Change assessed from before to after the intervention (6 weeks in study A, on average 7 days in study B)	Maximal voluntary isometric contraction of m. quadriceps femoris

Secondary Outcome Measures

Name	Time	Method
Maximal oxygen consumption	Change assessed from before to after the 6 week intervention	VO2max during incremental exercise
Skeletal muscle mitochondrial respiration	Change assessed from before to after the intervention (6 weeks in study A, on average 7 days in study B)	High resolution respirometry
Fiber cross-sectional area	Change assessed from before to after the intervention (6 weeks in study A, on average 7 days in study B)	Immunohistochemistry to determine fiber cross-sectional area
Functional exercise capacity	Change assessed from before to after the 6 week intervention (only in individuals with COPD)	Number of repetitions achieved during a 1-minute sit-to-stand test
Satellite cells	Change assessed from before to after the intervention (6 weeks in study A, on average 7 days in study B)	Immunohistochemistry to determine number of satellite cells
Lean mass	Change assessed from before to after the 6 week intervention	Lean mass assessed by dual X-ray absorptiometry (DXA)
Myonuclei	Change assessed from before to after the intervention (6 weeks in study A, on average 7 days in study B)	Immunohistochemistry to determine number of myonuclei

Trial Locations

Locations (1)

August Krogh Building; 🇩🇰 Copenhagen, Denmark