Genomic Changes in Childhood Acute Lymphoblastic Leukemia

• Conditions: Acute Lymphoblastic Leukemia

• Registration Number: NCT01089907
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

To study the genomics with cell cycle and lymphocyte differentiation in disease, remission and relapse of childhood acute lymphoblastic leukemia. Then correlate these data with age, white cell count, cytogenetic changes, response to the chemotherapy and prognosis.

Detailed Description

In order to know the genomic evolution of childhood acute lymphoblastic leukemia, we will collect bone marrow (10c.c.) at diagnosis, remission and relapse. We will do the following genes in addition to gene-chip including IKZF1,ETV6, EBF1, NR3C1, RAG1/G2, TCF3, BTLA, PAX5,LEF1, ERG and VPREB1.We will study the gene dosages and degree of methylation. The estimated patients numbers will be 300-400. Then we will correlate these data with patients'age, white blood cell count at diagnosis, cytogenetic abnormalities, response to the chemotherapy and prognosis.

Study Timeline

• Status Verified: 2010-03
• Study First Submitted: 2010-03-17
• Study First Submitted QC: 2010-03-18
• Last Update Submitted: 2010-03-18
• Study First Posted: 2010-03-19
• Last Update Posted: 2010-03-19
• Study Start: 2010-04
• Primary Completion: 2013-01
• Study Completion: 2013-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

1. patients diagnosed as acute lymphoblastic leukemia
2. age less than or equal to 18 years old
3. signed informed consent

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Exclusion Criteria

1. who is not acute lymphoblastic leukemia
2. who did not sign informed consent

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan