Strain-Encoded Cardiac Magnetic Resonance Imaging for Dobutamine Stress Testing

Completed

• Conditions: Coronary Artery Disease

• Registration Number: NCT00758654
• Lead Sponsor: Heidelberg University

Brief Summary

The purpose of this study is to compare the diagnostic value of SENC to that provided by conventional wall motion analysis for the detection of inducible ischemia during DS-MRI.High-dose dobutamine stress magnetic resonance imaging (DS-MRI) is safe and feasible for the diagnosis of coronary artery disease (CAD) in humans. However, the assessment of cine scans relies on the visual interpretation of regional wall motion, which is subjective. Recently, Strain-Encoded MRI (SENC) has been proposed for the direct color-coded visualization of myocardial strain.

Detailed Description

The assessment of inducible regional wall motion abnormalities during high-dose dobutamine stress magnetic resonance imaging (DS-MRI) is an established clinical method with high diagnostic and prognostic value for the evaluation of patients with coronary artery disease (CAD). However, the assessment of cine images relies on the visual interpretation of regional wall motion, which is subjective, and objective approaches for the detection of inducible ischemia with DS-MRI are still lacking.

In our study Strain-Encoded-MRI (SENC) is used for the objective color-coded evaluation of regional myocardial strain during DS-MRI in patients with intermediate to high pretest probability for CAD. We anticipated that this technique would exhibit enhanced sensitivity for the detection of anatomically significant CAD compared to conventional wall motion reading, with invasive coronary angiography used as the standard reference.

Study Timeline

• Study Start: 2007-01
• Study First Submitted: 2008-09-23
• Study First Submitted QC: 2008-09-23
• Study First Posted: 2008-09-25
• Primary Completion: 2011-01
• Study Completion: 2011-01
• Status Verified: 2012-03
• Last Update Submitted: 2012-03-28
• Last Update Posted: 2012-03-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 320

Inclusion Criteria

• Suspected or known coronary artery disease

Exclusion Criteria

• General contraindication for a dobutamine stress or for an MRI examination
• Age < 18 yrs

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Detection of coronary artery disease (>50% diameter stenosis) by invasive angiography	3 weeks

Secondary Outcome Measures

Name	Time	Method
Long-term mortality and MACE	2 years

Trial Locations

Locations (1)

University of Heidelberg, Department of Cardiology; 🇩🇪 Heidelberg, Germany