A Study of Microcirculatory Function in Type 2 Myocardial Infarction (T2MI)

Not yet recruiting

• Conditions: Myocardial Infarction; Coronary Microvascular Disease

• Registration Number: NCT05793567
• Lead Sponsor: Mayo Clinic

Brief Summary

The purpose of this research is to find out if patients with Type 2 Myocardial Infarction (T2MI) without significant epicardial coronary artery disease (CAD) have a greater chance of having coronary microvascular disease (CMD).

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-03-20
• Study First Submitted QC: 2023-03-30
• Study First Posted: 2023-03-31
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-25
• Last Update Posted: 2025-02-27
• Study Start: 2025-07
• Primary Completion: 2027-04
• Study Completion: 2027-04

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 52

Inclusion Criteria

• Ability to give informed consent
• Structurally normal heart (normal LV and RV function, no more than mild valvular heart disease)
• For controls: atypical chest pain with indication for CMD testing
• For T2MI: meet criteria for T2MI according to the 4th Universal definition of MI (rise/fall of troponin with at least 1 value >99th centile+ evidence of symptoms or signs of myocardial ischemia)

Exclusion Criteria

• Acute coronary event (evidence of plaque rupture, fissure or dissection on coronary angiogram)
• Known to have angiographically significant CAD/pressure wire positive for epicardial CAD
• Inability to receive heparin products
• Allergy/contraindication to acetylcholine/adenosine/nitroglycerine products
• Prior coronary artery bypass grafting
• Pregnancy (if sexually active woman of reproductive age, need negative pregnancy test prior to proceeding with coronary angiography - this is standard of care in cath lab)
• Asthma with prior ICU admission due to bronchospasm/need for invasive ventilation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Coronary Flow Reserve (CFR)	Baseline	The CFR will be calculated as a ratio of coronary flow at peak hyperemia /coronary flow at rest.

Secondary Outcome Measures

Name	Time	Method
Backward Compression Wave (BCW)	Baseline	The BCW is a measure of increased microvascular resistance during systole.

Trial Locations

Locations (1)

Mayo Clinic Rochester; 🇺🇸 Rochester, Minnesota, United States