A STUDY OF CENTRAL AND MIXED VENOUS OXYGEN SATURATION WITH OUTCOMES IN OPEN HEART SURGERY PATIENTS BETWEEN TWO GROUPS CONVENTIONAL GENERAL ANAESTHESIA AND COMBINED WITH REGIONAL ANESTHESIA

Phase 4

Completed

• Conditions: Health Condition 1: null- Patients with Coronary artery diseases require open heart bypass surgery

• Registration Number: CTRI/2018/05/013902
• Lead Sponsor: Cardiac Anesthesiology Dept

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2013-11-25
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

To investigate the impact of high thoracic epidural analgesia in patients undergoing off-pump coronary artery bypass surgery on:

Mixed venous oxygen saturation

Central venous oxygen saturation

Early post operative outcome

Specific Objectives:

To investigate the impact of high thoracic epidural analgesia on early clinical outcome in patients undergoing off-pump coronary artery bypass surgery on:

1.To compare the central venous and mixed venous oxygen saturation during intra-operative period and time for extubation and length of postoperative ICU stay.

2.To compare stress response, inotropic /vasodilatory support, pain outcome and analgesia requirements.

3.To evaluate other outcomes: new arrhythmia, post-operative blood loss, perioperative myocardial infarction, neurologic events, infective complication, if present.

4.To evaluate any other adverse effects during the study period.

Exclusion Criteria

Patients with abnormal coagulation profiles,

patients requiring salvage CABG,

With cariogenic shock,

associated heart valve pathology,

anti-platelet therapy continuing,

local infection, renal, metabolic, neurological,psychiatric disorders were excluded from the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mixed and central venous oxygen saturation were higher and less ICU stay and preoperative complications in thoracic epidural group than general anaesthesia group of patients undergoing off pump CABG at the end of surgeryTimepoint: Mixed and central venous oxygen saturation were higher during grafting and at end of surgery and ICU stay were less and less number of perioperative complications in thoracic epidural group than general anaesthesia group of patients undergoing off pump CABG

Secondary Outcome Measures

Name	Time	Method
Serum cortisol, serum lactateTimepoint: 5- 8 hr intraoperatively