Efficacy on inflammatory cytokine clearance of hemodialysis using medium cut off membrane dialyzer compare with online hemodiafiltration in chronic hemodialysis patients
Phase 3
- Conditions
- Improvement of uremic toxin clearance by novel hemodialysis modalityes and equipment can improve clinical outcome and survival of chronic dialysis patients.middle cut off dialyzerinflammatory cytokine clearanceonline hemodiafiltration
- Registration Number
- TCTR20230210004
- Lead Sponsor
- Faculty of Medicine, Khon Kaen University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- nknown
- Sex
- All
- Target Recruitment
- 36
Inclusion Criteria
Thrice weekly chronic hemodialysis more than 3 months
Hemodialysis via arteriovenous fistula or graft
Adequate hemodialysis define as spKt/V > 1.2 per session
Exclusion Criteria
Pregnancy
Vascular access dysfunction
Advanced staged of cancer
Advanced staged of cardiovascular disease
Life expectancy less than 1 year
Previous severe infection and/or hospitalization within 3 months
Previous history of severe anaphylaxis from dialyzer reaction
Currently recieved immunosuppressive drug
Currently received online hemodiafiltration
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method inflammatory cytokine clearance 8 weeks (pre-post hemodialysis inflammatory cytokine level)*100/pre dialysis inflammatory cytokine level
- Secondary Outcome Measures
Name Time Method Intradialytic albumin loss 8 week (pre-post hemodialysis albumin level)*100/pre hemodialysis albumin level ,intradialytic complication 8 weeks rate of intradialytic hypo/hypertension,Dialyzer reaction 8 weeks Rate of dialyzer reaction intrahemodialysis