0.05 mg Versus 0.1 mg Spinal Morphine for Reducing Morphine Requirement After Vaginal Hysterectomy

Phase 4

• Conditions: Pain
• Interventions: Drug: Morphine

• Registration Number: NCT01080911
• Lead Sponsor: Mahidol University

Brief Summary

This study aims to compare the effect of spinal morphine between the dose 0.05 mg and 0.1 mg on the amount of morphine during the first 24 hours postoperative.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-03
• Study First Submitted: 2010-03-03
• Study First Submitted QC: 2010-03-03
• Study First Posted: 2010-03-04
• Status Verified: 2011-09
• Last Update Submitted: 2011-09-05
• Last Update Posted: 2011-09-07
• Primary Completion: 2012-12
• Study Completion: 2012-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 72

Inclusion Criteria

• Female ASA 1-3
• Undergoing vaginal hysterectomy with/without anterior and posterior vaginoplasty
• Can operate PCA device

Exclusion Criteria

• History of allergy to the study drugs
• History of bleeding tendency
• History of infection at the back
• Patient refuse to have spinal anesthesia
• History of CAD or CVD

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
spinal morphine 0.05 mg	Morphine	spinal morphine 0.05 mg plus 0.5% heavy marcaine 3.5 ml
spinal morphine 0.1 mg	Morphine	spinal morphine 0.1 mg plus 0.5% heavy marcaine 3.5 ml

Primary Outcome Measures

Name	Time	Method
the amount of 24 hours morphine	24 hour

Trial Locations

Locations (1)

Faculty of Medicine, Siriraj Hospital, mahidol University; 🇹🇭 Bangkok, Thailand