NCT01597219CompletedPhase 2
A UK Multicentre Study of Haploidentical Stem Cell Transplantation in Patients With Haematological Malignancies
Conditions
Trial Snapshot
- Phase
- Phase 2
- Status
- Completed
- Sponsor
- University College, London
- Enrollment
- 77
- Locations
- 12
- Primary Endpoint
- Overall survival
Study Overview
Brief Summary
This trial investigates stem cell transplants from partially mismatched donors in patients with blood and bone marrow cancers. The trial will test two kinds of transplants - a full intensity transplant using a high dose of radiotherapy and chemotherapy, and a reduced intensity transplant with lower doses of chemotherapy and radiotherapy. Patients will be entered for the treatment pathway that is most appropriate for their level of health and fitness
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Single Group
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 16 Years to 70 Years (Child, Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Overall survival
Time Frame: 1 year post transplant
Secondary Outcomes
No secondary outcomes reported
Investigators
Study Sites (12)
Loading locations...
Similar Trials
Unknown
Phase 3
Haplo-SCT vs ASCT With or Without Decitabine in AML CR1Acute Myeloid LeukemiaNCT02059720The First Affiliated Hospital of Soochow University212
Completed
Early Phase 1
Donor Stem Cell Transplantation for Congenital ImmunodeficienciesInherited Immune DeficienciesNCT00426517National Institute of Allergy and Infectious Diseases (NIAID)48
Recruiting
Not Applicable
Precision Medicine for Stem Cell TransplantationHaematopoietic Stem Cell TransplantationNCT05567289University of Manchester300
Terminated
Phase 1
Donor Stem Cell Transplant in Treating Patients With High Risk Acute Myeloid LeukemiaAdult Acute Megakaryoblastic Leukemia (M7)Adult Acute Monoblastic Leukemia (M5a)Adult Acute Monocytic Leukemia (M5b)Adult Acute Myeloblastic Leukemia With Maturation (M2)Adult Acute Myeloblastic Leukemia Without Maturation (M1)Adult Acute Myeloid Leukemia in RemissionAdult Acute Myeloid Leukemia With 11q23 (MLL) AbnormalitiesAdult Acute Myeloid Leukemia With Del(5q)Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)Adult Acute Myelomonocytic Leukemia (M4)Adult Erythroleukemia (M6a)Adult Pure Erythroid Leukemia (M6b)Childhood Acute Erythroleukemia (M6)Childhood Acute Megakaryocytic Leukemia (M7)Childhood Acute Monoblastic Leukemia (M5a)Childhood Acute Monocytic Leukemia (M5b)Childhood Acute Myeloblastic Leukemia With Maturation (M2)Childhood Acute Myeloblastic Leukemia Without Maturation (M1)Childhood Acute Myeloid Leukemia in RemissionChildhood Acute Myelomonocytic Leukemia (M4)Recurrent Adult Acute Myeloid LeukemiaRecurrent Childhood Acute Myeloid LeukemiaSecondary Acute Myeloid LeukemiaUntreated Adult Acute Myeloid LeukemiaUntreated Childhood Acute Myeloid Leukemia and Other Myeloid MalignanciesNCT01801046University of Southern California10
Completed
Not Applicable
Stem Cell Transplant From Matched Unrelated or Partially Matched Related DonorsBlood CancerBlood and Marrow Transplant (BMT)NCT00186225Stanford University250