Effect of Exogenous Growth Hormone on Ocular Findings of Children With Precocious and Early Puberty: a Prospective Cohort Study
试验速览
- 阶段
- 不适用
- 入组人数
- 90
- 试验地点
- 2
- 主要终点
- Refraction Error
研究概览
简要总结
Body size and eye function play an essential role in adapting to the environment and human survival. Growth hormone is commonly recognized by its effect on the height of individuals; Although from an evolutionary perspective, the effects of growth hormone on eye development are more important. Although the effect of growth hormone on eye development has not been accurately determined, the results of a number of studies suggest the effect of growth hormone on eye development.
Despite the large number of studies that have investigated the effects of growth hormone on height growth, there are few studies that have investigated the effects of growth hormone on the eye.
To the best of our knowledge, no study has been conducted to investigate the effect of growth hormone on ocular findings of patients with early or precocious puberty. Therefore, we intend to investigate the effect of growth hormone on ocular findings of patients with early or precocious puberty.
详细描述
Investigators will achieve the following data from the participants:
-
Demographics
-
Past medical history
-
Bone and calendar age
4- Stage of puberty
5- Ocular examination
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 4 Years 至 11 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Sample group (with early or precocious puberty):
- •Children with precocious puberty based on Tanner classification
- •Girls 4 to 10 years old
- •Boys aged 4 to 11
- •No known eye problems including: history of eye trauma, eye surgery 5- lack of family history of glaucoma or increased intraocular pressure
- •Lack of previous history of receiving growth hormone
- •Lack of systemic disease or known syndromes
- •Consent to participate in the study
排除标准
- •Incidence of growth hormone adverse reactions leading to discontinuation of treatment
- •Changing the patient's treatment plan during the study
- •Ocular complications requiring treatment during the study
- •Unwillingness of the patient to continue participating in the study
结局指标
主要结局
Refraction Error
时间窗: 6 months
Comparison of the refraction error between the study groups
Axial Length
时间窗: 6 months
Comparison of the axial length between the study groups
次要结局
- Papillitis(6 months)
- Central Corneal Thickness(6 months)
研究者
Mohsen Pourazizi
Dr. Mohsen Pourazizi
Isfahan University of Medical Sciences