MedPath

An Observational Study in Patients With HER2 Positive Metastatic Breast Cancer (SystHERs Registry)

Completed
Conditions
Breast Cancer
Registration Number
NCT01615068
Lead Sponsor
Genentech, Inc.
Brief Summary

This multi-center, prospective observational study will evaluate the treatment patterns, and the safety in patients with HER2-positive (HER2+) metastatic breast cancer (MBC). Eligible patients will have an initial metastatic breast cancer diagnosis that has not been previously treated with systemic therapy; patients may be enrolled up to 6 months after the diagnosis. Data will be collected for up to 8 years.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
1007
Inclusion Criteria
  • Adult patients, >/=18 years of age
  • Initial diagnosis of HER2+ MBC, as diagnosed by the treating physician, no more than 6 months prior to study enrollment
  • Availability of cancer-specific historical data points in the patient's medical records
Exclusion Criteria
  • Any inability to provide informed consent

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Distribution of patients receiving unique treatment regimen/sequence of treatment regimensUp to 8 years
Secondary Outcome Measures
NameTimeMethod
Progression-free survival (PFS)Up to 8 years
Time-to-treatment failure (TTF)Up to 8 years
Post-progression survival (PPS)Up to 8 years
Patient-reported outcome assessment (PRO)Up to 8 years
Overall survival (OS)Up to 8 years
Response rate (RR)Up to 8 years
Safety: Incidence of adverse eventsUp to 8 years

Trial Locations

Locations (142)

Rush University Medical Center

🇺🇸

Chicago, Illinois, United States

Allegheny General Hospital; Transplantation Services

🇺🇸

Pittsburgh, Pennsylvania, United States

Univ of Pittsburgh Sch of Med; Magee-Womens Hospital

🇺🇸

Pittsburgh, Pennsylvania, United States

Virginia Mason Medical Center

🇺🇸

Seattle, Washington, United States

Boston Baskin Cancer Foundation

🇺🇸

Nashville, Tennessee, United States

Huntsman Cancer Institute; Oncology

🇺🇸

Salt Lake City, Utah, United States

Mercy Clinic Oklahoma Communties, Inc

🇺🇸

Oklahoma City, Oklahoma, United States

Sarah Cannon Research Inst.

🇺🇸

Nashville, Tennessee, United States

Kaiser Permanente Of Colorado

🇺🇸

Denver, Colorado, United States

Providence Cancer Center

🇺🇸

Portland, Oregon, United States

Cancer Care Associates

🇺🇸

Fresno, California, United States

Rocky Mountain Cancer Center - Denver

🇺🇸

Denver, Colorado, United States

St. Jude Heritage Healthcare; Virgiia K.Crosson Can Ctr

🇺🇸

Fullerton, California, United States

California Oncology of the Central Valley

🇺🇸

Fresno, California, United States

Arizona Oncology Associates, PC - NAHOA

🇺🇸

Sedona, Arizona, United States

Coastal Integrative Cancer Care

🇺🇸

San Luis Obispo, California, United States

Hematology Oncology P.C.

🇺🇸

Stamford, Connecticut, United States

Arizona Oncology

🇺🇸

Tucson, Arizona, United States

St. Vincent'S Hospital; Birmingham Hematology Oncology Associates, Llc

🇺🇸

Birmingham, Alabama, United States

South Bay Oncology Hematology Partners

🇺🇸

Campbell, California, United States

California Cancer Associates for Research & Excellence, Inc.

🇺🇸

Encinitas, California, United States

ROBERT A. MOSS, M.D., F.A.C.P., Inc

🇺🇸

Fountain Valley, California, United States

NEA Baptist Clinic

🇺🇸

Jonesboro, Arkansas, United States

Connecticut Oncology Group

🇺🇸

Middletown, Connecticut, United States

Univ of Calif, San Francisco; Breast Cancer Center

🇺🇸

San Francisco, California, United States

Lynn Cancer Institute - West

🇺🇸

Boca Raton, Florida, United States

Northwest Georgia Oncology Centers PC - Marietta

🇺🇸

Marietta, Georgia, United States

Orchard Healthcare Research Inc.

🇺🇸

Skokie, Illinois, United States

University of Miami; Dept Sylvester Cancer Center

🇺🇸

Deerfield Beach, Florida, United States

Central Coast Medical Oncology

🇺🇸

Santa Maria, California, United States

Lakeland Regional Cancer Center

🇺🇸

Lakeland, Florida, United States

Baptist - MD Anderson Cancer Center

🇺🇸

Jacksonville, Florida, United States

Genesis Cancer Center

🇺🇸

Hot Springs, Arkansas, United States

UCLA School of Medicine

🇺🇸

Los Angeles, California, United States

Minnesota Oncology Hematology, Pa

🇺🇸

Minneapolis, Minnesota, United States

University of South Alabama; Mitchell Cancer Institute

🇺🇸

Mobile, Alabama, United States

East Valley Hem/Onc Med Group; Metropolitan Hem Onc.

🇺🇸

Burbank, California, United States

Memorial Cancer Institute

🇺🇸

Hollywood, Florida, United States

Mary Bird Perkins Cancer Ctr

🇺🇸

Baton Rouge, Louisiana, United States

Medical Oncology LLC

🇺🇸

Baton Rouge, Louisiana, United States

West Michigan Cancer Center

🇺🇸

Kalamazoo, Michigan, United States

Hematology Oncology Services of Arkansas

🇺🇸

Little Rock, Arkansas, United States

Florida Oncology Associates

🇺🇸

Jacksonville, Florida, United States

Cancer Center of Kansas

🇺🇸

Wichita, Kansas, United States

Highlands Oncology Group

🇺🇸

Rogers, Arkansas, United States

Comprehensive Cancer Care

🇺🇸

Palm Springs, California, United States

McFarland Clinic

🇺🇸

Ames, Iowa, United States

Berkshire Hematology, Oncology Pc

🇺🇸

Pittsfield, Massachusetts, United States

Southdale Cancer Clinic U of M Medical Center, Fairview- Edina

🇺🇸

Edina, Minnesota, United States

MedStar Washington Hosp Center

🇺🇸

Washington, District of Columbia, United States

Western Maryland Health Sys

🇺🇸

Cumberland, Maryland, United States

Florida Cancer Specialists (St. Petersburg - St. Anthony's Professional Building)

🇺🇸

Saint Petersburg, Florida, United States

Alton Memorial Hospital; Outpatient Clinic and Infusion Center

🇺🇸

Alton, Illinois, United States

Summit Cancer Care PC

🇺🇸

Savannah, Georgia, United States

Oncology Specialists, S.C.

🇺🇸

Park Ridge, Illinois, United States

Southeastern Regional Medical Center

🇺🇸

Lumberton, North Carolina, United States

St. Joseph Medical Center

🇺🇸

Towson, Maryland, United States

Portsmouth Regional Hospital; Hem/Onc Clinic

🇺🇸

Portsmouth, New Hampshire, United States

Summit Medical Group

🇺🇸

Berkeley Heights, New Jersey, United States

North Shore Hem Onc Associates

🇺🇸

East Setauket, New York, United States

Gaston Hematology/Oncology

🇺🇸

Gastonia, North Carolina, United States

Space Coast Medical Associates

🇺🇸

Titusville, Florida, United States

St. John'S Mercy Medical Center; David C. Pratt Cancer Center

🇺🇸

Saint Louis, Missouri, United States

Onc & Hematology Specialists

🇺🇸

Denville, New Jersey, United States

Florida Cancer Specialists - Fort Myers (New Hampshire Ct)

🇺🇸

Fort Myers, Florida, United States

Florida Cancer Research Institute

🇺🇸

Plantation, Florida, United States

Mercy Oncology / Hematology Center; Oncology

🇺🇸

Portland, Maine, United States

Park Nicollet Clinic Cancer Center

🇺🇸

Saint Louis Park, Minnesota, United States

Southeast Nebraska Cancer Center;; Southeast Nebraska Hematology and Oncology

🇺🇸

Lincoln, Nebraska, United States

First Health of the Carolinas

🇺🇸

Pinehurst, North Carolina, United States

Peachtree Hematology & Oncology Consultants, Pc

🇺🇸

Atlanta, Georgia, United States

Comprehensive Cancer Centers of Nevada

🇺🇸

Las Vegas, Nevada, United States

Mid-Illinois Hematology

🇺🇸

Normal, Illinois, United States

Lafayette General Medical Center

🇺🇸

Lafayette, Louisiana, United States

Capitol Hematology & Oncology

🇺🇸

Silver Spring, Maryland, United States

Luckow Pavillion, Valley Hosp; Office of Clinical Trials

🇺🇸

Paramus, New Jersey, United States

Queens Hospital Center

🇺🇸

Jamaica, New York, United States

Flower Memorial Hospital

🇺🇸

Sylvania, Ohio, United States

Christian Hospital; Outpatient Cancer and Infusion Center

🇺🇸

Saint Louis, Missouri, United States

Temple University Hospital

🇺🇸

Philadelphia, Pennsylvania, United States

Beth Israel Comprehensive Cancer Center Pharmacy

🇺🇸

New York, New York, United States

Herbert Irving Comprehensive Cancer Center; Herbert Irving Pavillion

🇺🇸

New York, New York, United States

Montana Cancer Specialists

🇺🇸

Missoula, Montana, United States

Cancer & Hematology Centers of Western Michigan

🇺🇸

Grand Rapids, Michigan, United States

Hackensack University Medical Center

🇺🇸

Hackensack, New Jersey, United States

Hope A Women's Cancer Center

🇺🇸

Asheville, North Carolina, United States

Cancer Care Assoc-15th St

🇺🇸

Tulsa, Oklahoma, United States

South Carolina Oncology Associates - SCRI

🇺🇸

Columbia, South Carolina, United States

Center for Biomedical Research LLC

🇺🇸

Knoxville, Tennessee, United States

Kootenai Cancer Center

🇺🇸

Post Falls, Idaho, United States

Carroll County Cancer Center

🇺🇸

Westminster, Maryland, United States

Billings Clinic Research Center

🇺🇸

Billings, Montana, United States

Mercy Medical Ctr-North Iowa ; Mercy Cancer Center

🇺🇸

Mason City, Iowa, United States

University of Iowa

🇺🇸

Iowa City, Iowa, United States

Oncology Hematology Assoc

🇺🇸

Evansville, Indiana, United States

Associates in Oncology/Hematology P.C.

🇺🇸

Rockville, Maryland, United States

Jefferson City Medical Group

🇺🇸

Jefferson City, Missouri, United States

Metro Health Medical Center

🇺🇸

Cleveland, Ohio, United States

The Mary Imogene Bassett Hospi

🇺🇸

Cooperstown, New York, United States

Hematology & Oncology Assoc; North Eastern Pennsylvania

🇺🇸

Dunmore, Pennsylvania, United States

Texas Oncology, PA

🇺🇸

Waco, Texas, United States

Jackson Oncology Associates, PLLC

🇺🇸

Jackson, Mississippi, United States

Texas Oncology, P.A. - Fort Worth

🇺🇸

Fort Worth, Texas, United States

Texas Oncology-Baylor Sammons Cancer Center

🇺🇸

Dallas, Texas, United States

Mid Ohio Onc Hematology Inc

🇺🇸

Columbus, Ohio, United States

Hematology Oncology Associates; Carol G. Simon Ctr

🇺🇸

Morristown, New Jersey, United States

Cone Health Cancer Center

🇺🇸

Greensboro, North Carolina, United States

St. Joseph Regional Cancer Ct

🇺🇸

Bryan, Texas, United States

Dartmouth Hitchcock Medical Center; Gastroenterology Section

🇺🇸

Lebanon, New Hampshire, United States

Chattanooga Oncology and Hematology Associates, PC

🇺🇸

Chattanooga, Tennessee, United States

Guthrie Clinic

🇺🇸

Sayre, Pennsylvania, United States

Texas Oncology - Houston (Gessner)

🇺🇸

Houston, Texas, United States

Hendrick Cancer Center

🇺🇸

Abilene, Texas, United States

Texas Oncology - Paris

🇺🇸

Paris, Texas, United States

Tyler Hematololgy Oncology, PA

🇺🇸

Tyler, Texas, United States

Northern Utah Associates

🇺🇸

Ogden, Utah, United States

Texas Oncology, P.A.; Duke Slayton Cancer Center

🇺🇸

Webster, Texas, United States

West Virginia University Hospitals Inc

🇺🇸

Morgantown, West Virginia, United States

Lynchburg Hem Onc Clinic Inc

🇺🇸

Lynchburg, Virginia, United States

University of Wisconsin

🇺🇸

Madison, Wisconsin, United States

Peninsula Cancer Institute

🇺🇸

Newport News, Virginia, United States

Shenandoah Oncology Associates

🇺🇸

Winchester, Virginia, United States

Cancer Alliance of Nebraska

🇺🇸

Omaha, Nebraska, United States

Columbia Saint Mary's; Medical Oncology

🇺🇸

Milwaukee, Wisconsin, United States

University of Southern California

🇺🇸

Los Angeles, California, United States

Kingsport Hematology Oncology Associates

🇺🇸

Kingsport, Tennessee, United States

Carle Cancer Center

🇺🇸

Urbana, Illinois, United States

Baptist Hospital East

🇺🇸

Louisville, Kentucky, United States

Yale Cancer Center

🇺🇸

New Haven, Connecticut, United States

Md Anderson Cancer Center Orlando

🇺🇸

Orlando, Florida, United States

James Graham Brown Cancer Center, University of Louisville

🇺🇸

Louisville, Kentucky, United States

Research Medical Center; Pharmacy

🇺🇸

Kansas City, Missouri, United States

Charleston Hematology Oncology

🇺🇸

Charleston, South Carolina, United States

Medical Univ of South Carolina

🇺🇸

Charleston, South Carolina, United States

Virginia Cancer Institute

🇺🇸

Richmond, Virginia, United States

Lancaster Cancer Center, Ltd.

🇺🇸

Lancaster, Pennsylvania, United States

Texas Oncology

🇺🇸

Bedford, Texas, United States

Texas Oncology- El Paso Cancer Treatment Center Gateway

🇺🇸

El Paso, Texas, United States

Signal Point Clinical; Research Center, LLC

🇺🇸

Middletown, Ohio, United States

Texas Oncology, P.A. - McAllen; South Texas Cancer Center-McAllen

🇺🇸

McAllen, Texas, United States

Sutter Pacific Medical Foundation

🇺🇸

Santa Rosa, California, United States

Mile High Oncology

🇺🇸

Littleton, Colorado, United States

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