A Pharmacokinetic and Pharmacogenetic Study in Patients Receiving Sulfamethoxazole-trimethoprim Therapy
试验速览
- 阶段
- 不适用
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- High performance liquid chromatography for drug plasma concentration
研究概览
简要总结
In this study, we aim to investigate the incidence of the adverse reactions, the effectiveness and the gene polymorphism associated with the plasma level of sulfamethoxazole-trimethoprim and their metabolites (including N4-acetyl-sulfamethoxazole, sulfamethoxazole hydroxylamine and sulfamethoxazole-nitroso). And we also aim to investigate the factors associated with the sulfamethoxazole-trimethoprim induced acute psychosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •males and females aged 20 years or older
- •using oral or intravenous form of sulfamethoxazole-trimethoprim
排除标准
- •patients who are under 20 years of age
结局指标
主要结局
High performance liquid chromatography for drug plasma concentration
时间窗: Participants will be followed for the duration of the treatment course, an expected average of 21 days
The plasma concentration will not be measured until the patient's treatment course completed.
次要结局
未报告次要终点
研究者
National Taiwan University Hospital
National Taiwan University Hospital
National Taiwan University Hospital