AChE-activity in critically ill patients with suspected septic encephalopathy: a prospective, single-centre study

• Conditions: septic associated encephalopathy; F05.9; Delirium, unspecified

• Registration Number: DRKS00020542
• Lead Sponsor: Klinik für Anästhesiologie, Universitätsklinikum Ulm, Leiter Interdisziplinäre Operative Intensivmedizin

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2018-03-31
• Study Start: 2020-01-27
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 241

Inclusion Criteria

Necessity of intensive care therapy (emergencies or elective operated patients with postoperative ICU monitoring)
Age> 18 years
Minimum stay in the intensive care unit of at least 24 hours
sufficient knowledge of German (understanding and language)
Agreement to participate in the study

Exclusion Criteria

Age > 18 years
less than 2 consecutive readings of esterase activity
missing declaration of consent (verbally and or in writing)

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Is the longitudinal recording of the erythrocytic acetylcholinesterase activity in intensive care patients with sepsis and the clinical suspicion of a septic associated encephalopathy suitable for confirming this as a differential diagnosis within the syndrome complex delirium and does the erythrocytic AChE-activity differ statistically significant in septic patients with suspicion of a septic associated encephalopathy compared to non septic critically ill patients?<br><br><br><br><br><br><br><br>

Secondary Outcome Measures

Name	Time	Method
Delirium incidence,<br>number of patients with sepsis within the enrolled patient population, <br>activity of butyrylcholinesterase activity