Comparison of Neostigmine versus Sugammadex after muscle paralysis by muscle relaxants by doing ultrasonography of diaphragm.
Not Applicable
Not yet recruiting
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2023/05/052678
- Lead Sponsor
- Dr Prasanta Kumar Das
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Patients undergoing elective non-cardiac
surgery
2.ASA grade I to III
3.AGE- 18- 70 Years
Exclusion Criteria
1.Emergency surgery
2.Refusal to treatment
3.Allergy to study drug
4.Renal and hepatic failure
5.Pregnant and nursing mother
6.Diaphragmatic palsy
7.Poor image quality
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the incidence of PORC defined by diaphragmatic thickening fraction â?¤0.36 , <br/ ><br>between two groups after administration of Neostigmine or Sugammadex assessed by diaphragm USG <br/ ><br>Timepoint: We will measure the thickening fraction of diaphragm by ultrasonography at three readings. The baseline will be taken before induction, just before extubation, at 30 minutes after extubation in postop area. <br/ ><br>All the outcomes will be assessed for 24 hours for taking the results into account. <br/ ><br>
- Secondary Outcome Measures
Name Time Method To compare: <br/ ><br> <br/ ><br>1)Time to achieve TOF ratio â?¥ 0.9 or four twitches since administration of last dose of muscle relaxant (whichever is later) <br/ ><br> <br/ ><br>2)Time to achieve TOF ratio â?¥ 0.9 or four twitches after administration of reversal agent (whichever is later) <br/ ><br> <br/ ><br>3)Postoperative pulmonary complications (PPC) within 24 hours [ PPC defined by SpO2 less than 90% or requiring oxygen therapy to maintain SpO2 more than 95% ] <br/ ><br> <br/ ><br>3)Incidence of adverse effects <br/ ><br>Timepoint: within 24 hours