Comparison of Neostigmine and Sugammadex as muscle paralysis reversal agents by assessing respiratory muscle strength and lower lung collapse after operation with the help of Diaphragm, Lung, and respiratory muscle ultrasonography
Phase 4
Not yet recruiting
- Registration Number
- CTRI/2024/07/069731
- Lead Sponsor
- All India Institute of Medical Sciences Patna
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
American Society of Anaesthesiologists physical status 1-2
Able to give Informed consent.
Exclusion Criteria
significant liver and kidney disease.
Allergic to neostigmine or sugammadex.
Any history of neuromuscular disorder.
History of Chronic Obstructive Pulmonary Disease.
Pregnancy or nursing women
Open Abdominal surgeries with subcostal incisions.
Patients with arrhythmias or taking anti-arrhythmic drugs.
surgeries anticipated to last more than 3 hours.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To assess the recovery of respiratory muscle strength by assessing the thickening fraction of internal oblique muscleTimepoint: calculated at 30 minutes and 120 minutes after giving reversal agent and compare with baseline values
- Secondary Outcome Measures
Name Time Method To assess the post operative atelectasis by the modified LUS score based on lung ultrasound. <br/ ><br>To assess the recovery of diaphragm, by assessing diaphragm excursion. <br/ ><br> To assess the displacement of hyoid bone by initially assessing the length of the geniohyoid muscle in the mid-sagittal plane between hyoid bone and mandibleTimepoint: calculated at 30 minutes and 120 minutes after giving reversal agent and compare with baseline values