Can taking probiotics ('friendly' bacteria) reduce upper respiratory tract infections in healthcare workers?
Not Applicable
Completed
- Conditions
- pper respiratory tract infectionRespiratory
- Registration Number
- ISRCTN90136957
- Lead Sponsor
- Cultech (United Kingdom)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 104
Inclusion Criteria
1. Male or Female aged between 18 and 70 years
2. Must work in a health-care setting
Exclusion Criteria
1. Unable to give written informed consent
2. Not prepared to provide blood and saliva samples as required
3. Taking the products/medications that stimulate immune function/inflammation. For example: ß glucans, isoprinosine (methisoprinolum), ribomunyl, immunomodulators lysate of bacteria
4. Have taken probiotic supplements within 2 weeks of trial start
5. Pregnant or lactating
6. Received oral antibiotics within 3 weeks of trial start
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence and duration of URTI symptoms (Patient records at 4 months)
- Secondary Outcome Measures
Name Time Method <br> 1. Incidence and duration of absence from work, antibiotic usage and visits to general practitioners (Daily records)<br> 2. General well-being and health assessed (Quality of life questionnaire; 0, 2, 4 months)<br> 3. Microbiota composition/functionality. (Traditional and NGS; 0, 4 months)<br> 4. Bodyweight, blood pressure and peak flow (0, 2, 4 months)<br> 5. Analysis of biomarkers in blood/urine/saliva (0, 4 months)*<br> *The methods of analysis for blood/urine/saliva have yet to be finalised<br>