eucine-rich alpha-2 glycoprotein (LRG) levels in the gingival crevicular fluid of periodontally healthy and periodontitis patients.

Not Applicable

• Conditions: Health Condition 1: K053- Chronic periodontitis

• Registration Number: CTRI/2022/11/047543
• Lead Sponsor: T.P.C.Ts Terna Dental College

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 25 July 2023

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

Subjects between the age group of 26 to 49 years. Subjects who have not received periodontal therapy, in the previous six

months.

Subjects who readily give informed consent for the study.

subjects with gingival index 0, clinical attachment level 0 will be

included as periodontally Healthy.

Subjects with gingival index greater than and equal to 1, maximum pocket probing depth less than and equal to 4mm,

mostly horizontal bone loss, clinical attachment level 1-2 mm affecting less than and equal to 30% teeth involved with radiographic bone loss extending to the coronal-third (less than 15%) and no teeth loss due to periodontitis will be included as stage 1 grade A periodontitis.

Exclusion Criteria

Patients with any systemic disorders

Patients with a history of smoking

Pregnant and lactating females. Patients who have received any periodontal treatment in the previous 6 months

Subjects who have received antibiotics, anti-inflammatory drugs or any

other drugs within 6 months.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1.To determine the levels of LRG in gingival crevicular fluid of periodontally <br/ ><br>healthy patients. <br/ ><br>2.To determine the levels of LRG in gingival crevicular fluid of stage 1 grade A <br/ ><br>periodontitis patient. <br/ ><br>3. To compare levels of LRG in gingival crevicular fluid of periodontally healthy <br/ ><br>and stage 1 grade A periodontitis patient. <br/ ><br>4. To correlate effect of scaling and root planning on level of leucine-rich alpha 2 glycoprotein (LRG) in gingival crevicular fluid in stage 1 grade A periodontitis <br/ ><br>patientsTimepoint: At baseline and at 6 weeks

Secondary Outcome Measures

Name	Time	Method
To correlate between clinical parameters like plaque index, Gingival Index, Probing Depth, Clinical Attachment Levels, Bleeding On Probing and levels of <br/ ><br>leucine-rich alpha-2 glycoprotein (LRG) in gingival crevicular fluid.Timepoint: at baseline and plaque index, Gingival Index, Probing Depth, Clinical Attachment Levels, Bleeding On Probing at 6 weeks in stage 1 grade A periodontitis in patients.